Results 61 to 70 of about 14,132 (182)
Residues involved in co‐factor and substrate binding of the short‐chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania [PDF]
European Journal of Biochemistry, 1998 The Leishmania short‐chain dehydrogenase/reductase gene ptr1 has been isolated while characterizing antifolate‐resistant Leishmania mutants. PTR1 is active as a tetramer and can reduce pterins and folates. PTR1 has several of the hallmarks of the short chain dehydrogenase/reductase family, including a glycine rich co‐factor binding site at its N ...
Éric Leblanc +3 more
openalex +4 more sources
On the expressiveness and monitoring of metric temporal logic [PDF]
, 2019 It is known that Metric Temporal Logic (MTL) is strictly less expressive than the Monadic First-Order Logic of Order and Metric (FO[
Ho, H.M., Ouaknine, J, Worrell, J
core +2 more sources
In-Silico Analyses of Sesquiterpene-Related Compounds on Selected Leishmania Enzyme-Based Targets
Molecules, 2014 A great number of sesquiterpenes are reported in the available literature as good antileishmanial leads. However, their mode of action at the molecular level has not been elucidated.
Freddy A. Bernal, Ericsson Coy-Barrera
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Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs [PDF]
, 2016 Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification ...
Anabela Cordeiro-da-Silva +38 more
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Plants, 2020 This paper is focused on demonstrating with a real case that Ethnobotany added to Bioinformatics is a promising tool for new drugs search. It encourages the in silico investigation of “challua kaspi”, a medicinal kichwa Amazonian plant (Aspidosperma ...
Diana Morales-Jadán +3 more
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New Englanders, Out of Their Minds [PDF]
, 2016 By comparing The Witch (2016) to The Shining (Stanley Kubrick, 1980), I argue that Robert Eggers\u27 new film contests Perry Miller\u27s sympathetic reading of the Puritans offered as the formation of American Studies, returning us to the 19th century ...
Metz, Walter C
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Transcriptomic analysis of longitudinal Burkholderia pseudomallei infecting the cystic fibrosis lung [PDF]
, 2018 The melioidosis bacterium, Burkholderia pseudomallei, is increasingly being recognised as a pathogen in patients with cystic fibrosis (CF). We have recently catalogued genome-wide variation of paired, isogenic B.
Bell, Scott C. +5 more
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Pharmaceutics, 2022 Isopropyl gallate (IPG) is a polyphenol obtained from alterations in the gallic acid molecule via acid catalysis with previously reported leishmanicidal and trypanocidal activities.
Danielly Silva de Melo +11 more
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Using shared-data localization to reduce the cost of inspector-execution in unified-parallel-C programs [PDF]
, 2016 Programs written in the Unified Parallel C (UPC) language can access any location of the entire local and remote address space via read/write operations. However, UPC programs that contain fine-grained shared accesses can exhibit performance degradation.
Alvanos, Michail +4 more
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BMC Chemistry, 2022 Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted-4(3H)-quinazolinones were synthesized via cyclization, condensation, and
Girma Worku Seifu +4 more
doaj +1 more source