Results 231 to 240 of about 16,818 (287)

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Genetics and Epigenetics of Human Pubertal Timing: The Contribution of Genes Associated With Central Precocious Puberty. [PDF]

J Endocr Soc
Canton APM, Macedo DB, Abreu AP, Latronico AC.   +3 more
europepmc   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

The causal role of male pubertal timing for the development of externalizing and internalizing traits: results from Mendelian randomization studies. [PDF]

Psychol Med
Dinkelbach L, Peters T, Grasemann C, Hinney A, Hirtz R.   +4 more
europepmc   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Sleep Disorders in Klinefelter Syndrome and Other Sex Chromosome Aneuploidies: A Narrative Review

Andrology, EarlyView.
ABSTRACT Background Sex chromosome aneuploidies (SCAs) are among the most frequent types of chromosomal aneuploidies and include Klinefelter syndrome (47,XXY and higher‐grade variants), 47,XYY syndrome, Turner syndrome (45,X), and trisomy X (47,XXX).
Roberto Paparella, Fabiola Panvino, Ida Pucarelli, Luigi Tarani   +3 more
wiley   +1 more source

Early Pubertal Timing, Suicidality, and Self-Injurious Behaviors in Preadolescents: Evidence for Concurrent and Emergent Risk Prediction. [PDF]

J Am Acad Child Adolesc Psychiatry
Luking KR, Hennefield L, Ortin-Peralta A, Wright AJ, Whalen DJ.   +4 more
europepmc   +1 more source

Semen Quality in Transgender Individuals Seeking Fertility Preservation

Andrology, EarlyView.
ABSTRACT Background Transgender individuals assigned male at birth (AMAB) may choose to preserve their fertility prior to starting gender‐affirming hormone therapy (GAHT). However, limited data exist regarding the baseline reproductive and hormonal characteristics of this population before and after GAHT.
Maurizio De Rocco Ponce, Eden Troka, Massimiliano Raffo, Luis Miguel Malca Caballero, Alberto Ferlin, Andrea Salonia, Eduard Ruiz Castañé, Alberto Scala, Andrea Garolla, the Gender Incongruence Interdisciplinary Group (GIIG), Andrea Garolla, Anna Aprile, Camillo Barbisan, Anna Belloni Fortina, Valentina Camozzi, Elena Campello, Annamaria Cattelan, Chiara Ceolin, Fabrizio Dal Moro, Giorgio De Conti, Angela Favaro, Alberto Ferlin, Francesco Francini Pesenti, Michela Gatta, Marta Ghisi, Sandro Giannini, Laura Guazzarotti, Massimo Iafrate, Paolo Meneguzzo, Marina Miscioscia, Giulia Musso, Giancarlo Ottaviano, Corrado Marchese Ragona, Carlo Saccardi, Lolita Sasset, Rossana Schiavo, Giuseppe Sergi, Paolo Simioni, Benedetta Tascini, Eleonora Vania, Elisa Varotto, Francesca Venturini, Tommaso Vezzaro, Fabrizio Vianello   +43 more
wiley   +1 more source

Lack of a genetic risk continuum between pubertal timing in the general population and idiopathic hypogonadotropic hypogonadism. [PDF]

J Neuroendocrinol
Plummer L, Balasubramanian R, Stamou M, Campbell M, Dewan P, Bryant N, Salnikov K, Lippincott M, Seminara S.   +8 more
europepmc   +1 more source