Results 41 to 50 of about 1,980,181 (285)

Genes underlying delayed puberty

Molecular and Cellular Endocrinology, 2018
The genetic control of pubertal timing has been a field of active investigation for the last decade, but remains a fascinating and mysterious conundrum.
S. Howard
semanticscholar   +1 more source

Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities

Advanced Materials, EarlyView.
As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas, Bilal Kizilaslan, Aastha Shah, Jason F. Hou, Yoonsoo Shin, Alejandra Hernandez Moyers, Claudia Lozano, Canan Dagdeviren   +7 more
wiley   +1 more source

Iatrogenic chimerism in a patient with Fanconi anemia and delayed puberty

Гинекология, 2020
The article presents a clinical case of delayed puberty in a 13-year-old girl with Fanconi anemia who was sent to the Department of gynecology of children and adolescents for removal of the sexual glands due to the detection of a Y-chromosome in the ...
Zaira Kh. Kumykova, Irina A. Kiseleva, Zalina K. Batyrova, Olga A. Buyanovskaya   +3 more
doaj   +1 more source

Early onset of puberty in an obese boy with Klinefelter syndrome [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2016
Klinefelter syndrome (KS) is one of the most common disease entities characterized by X-chromosomal aberration causing the primary hypogonadism in adult men. Patients with KS seem to be typically characterized by tall, slender bodies with delayed puberty
Byoung-Wook Cho, Seung-Eun Kwon, Soon-Ki Kim, Taek Lee, Jee-Young Han, Ji-Eun Lee   +5 more
doaj   +1 more source

Genetic architecture of self-limited delayed puberty and congenital hypogonadotropic hypogonadism

Frontiers in Endocrinology, 2023
Distinguishing between self limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) may be tricky as they share clinical and biochemical characteristics. and appear to lie within the same clinical spectrum.
Valeria Vezzoli, Faris Hrvat, Giovanni Goggi, Silvia Federici, Biagio Cangiano, Biagio Cangiano, Richard Quinton, Richard Quinton, Luca Persani, Luca Persani, Marco Bonomi, Marco Bonomi   +11 more
doaj   +1 more source

The Intricate Relationship between Chronic Undernutrition, Impaired Linear Growth and Delayed Puberty

Innocenti Working Papers, 2018
Chronic undernutrition is characterized by long-term exposure to food of insufficient quality and inadequate quantity, including restricted intake of energy, protein, fat, micronutrients, essential amino acids, vitamins and minerals.
S. Campisi, B. Carducci, O. Söder, Z. Bhutta   +3 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Investigation of montelukast effect on rosuvastatin induced late puberty in rats

Journal of Human Reproductive Sciences, 2022
Background: Puberty is a critical process for the development of sexual organs and reproductive ability. It is triggered and regulated by the hormones.
Tamadir Hamid Wadi Aledani, Manal Nasser Al-Hayder, Suha Haitham Mohammed, Rawaa Salim Al-Mayyahi   +3 more
doaj   +1 more source

Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty

Journal of Clinical Endocrinology and Metabolism, 2017
Context: Self-limited delayed puberty (DP) is often associated with a delay in physical maturation, but although highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of puberty have identified multiple
S. Howard, L. Guasti, Ariel H. B. Poliandri, A. David, C. Cabrera, M. Barnes, K. Wehkalampi, S. O’Rahilly, C. Aiken, A. Coll, Marcella K. Ma, D. Rimmington, G. Yeo, L. Dunkel   +13 more
semanticscholar   +1 more source

Interpretation of reproductive hormones before, during and after the pubertal transition—Identifying health and disordered puberty

Clinical Endocrinology, 2021
Puberty is a process of transition from childhood to adult reproductive capacity, governed by the reactivation of the hypothalamic–pituitary–gonadal axis after a long period of dormancy in mid‐childhood.
S. Howard
semanticscholar   +1 more source