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Current Opinion in Obstetrics & Gynecology, 2014 
Precocious puberty continues to elicit great interest and concern among medical practitioners, as well as the public.Studies have elucidated neural regulation of puberty by kisspeptin, neurokinin B, and other factors. Cohort studies from the North America and Europe suggest that the age of thelarche may be earlier than determined 2 decades ago, and ...
E Kirk, Neely, Stephanie S, Crossen
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Precocious puberty continues to elicit great interest and concern among medical practitioners, as well as the public.Studies have elucidated neural regulation of puberty by kisspeptin, neurokinin B, and other factors. Cohort studies from the North America and Europe suggest that the age of thelarche may be earlier than determined 2 decades ago, and ...
E Kirk, Neely, Stephanie S, Crossen
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The Indian Journal of Pediatrics, 1997 
Puberty occurring before the age of 8 years in girls and 9 years in boys in considered precocious. The numerous causes of precocity can be classified as central or peripheral. Central or true precocious puberty (CPP) is due to premature activation of the hypothalamopituitary-gonadal axis and is isosexual.
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Puberty occurring before the age of 8 years in girls and 9 years in boys in considered precocious. The numerous causes of precocity can be classified as central or peripheral. Central or true precocious puberty (CPP) is due to premature activation of the hypothalamopituitary-gonadal axis and is isosexual.
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Pediatrics In Review, 1990 
The child with premature sexual development requires a thorough history, physical, and appropriate laboratory evaluation. The physician and other medical staff should remain sensitive to the family's concerns and the child's emotional adaptation. Counseling and open discussion of the psychosocial and sexual issues may greatly assist both the child and ...
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The child with premature sexual development requires a thorough history, physical, and appropriate laboratory evaluation. The physician and other medical staff should remain sensitive to the family's concerns and the child's emotional adaptation. Counseling and open discussion of the psychosocial and sexual issues may greatly assist both the child and ...
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Pediatrics, 1950 
Five cases of probable hypophyseal precocious puberty of constitutional origin and one case of hypophyseal precocious puberty associated with a hypothalamic lesion are presented. The physiologic alterations involved are briefly discussed.
C W, LLOYD, J, LOBOTSKY, M, MORLEY
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Five cases of probable hypophyseal precocious puberty of constitutional origin and one case of hypophyseal precocious puberty associated with a hypothalamic lesion are presented. The physiologic alterations involved are briefly discussed.
C W, LLOYD, J, LOBOTSKY, M, MORLEY
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New England Journal of Medicine, 1999 
Normal puberty starts when pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus begins. This triggers the release of luteinizing hormone and follicle-stimulating hormone from the pituitary. In both sexes, these pituitary hormones then activate gonadal function.
Brunner, H.G., Otten, B.J.
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Normal puberty starts when pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus begins. This triggers the release of luteinizing hormone and follicle-stimulating hormone from the pituitary. In both sexes, these pituitary hormones then activate gonadal function.
Brunner, H.G., Otten, B.J.
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The Indian Journal of Pediatrics, 2006 
Growth in precocious puberty is a subject of concern to families and clinicians alike. The definition of precocious puberty and the role of obesity in the age of onset have also been areas of debate since the Lawson Wilkins Society recommended a lowering of the age of onset of precocious puberty in US girls.
Garry L. Warne +2 more
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Growth in precocious puberty is a subject of concern to families and clinicians alike. The definition of precocious puberty and the role of obesity in the age of onset have also been areas of debate since the Lawson Wilkins Society recommended a lowering of the age of onset of precocious puberty in US girls.
Garry L. Warne +2 more
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The Treatment of Precocious Puberty
Endocrinology and Metabolism Clinics of North America, 1991Long-acting GnRH agonists are the treatment of choice for central precocious puberty. GnRH agonists are not effective in peripheral precocious puberty, but a number of other agents, including medroxyprogesterone acetate, ketoconazole, testolactone, and androgen antagonists, may be useful.
Dennis M. Styne, Mark D. Wheeler
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Gonadotropin Independent Precocious Puberty
Journal of Pediatric Endocrinology and Metabolism, 1998Clinicians should now be fully aware of this intriguing condition of GIPP. The condition is characterized by pubertal sex steroid concentrations and gametogenesis in the presence of prepubertal or suppressed gonadotrophins. In patients with MPP especially without a family history, one should exclude the possibility of pseudoprecocious puberty due to ...
Wang, Q, Low, LCK
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Management of Precocious Puberty
New England Journal of Medicine, 1985Precocious sexual development is a stressful condition for both the affected child and the family.1 Because of its relative rarity, numerous causes, and psychosocial complications, few other condit...
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