Results 61 to 70 of about 16,429,787 (245)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Survey on SAP and its application in public-key cryptography

Journal of Mathematical Cryptology, 2020
The concept of the semigroup action problem (SAP) was first introduced by Monico in 2002. Monico explained in his paper that the discrete logarithm problem (DLP) can be generalized to SAP. After defining the action problem in a semigroup, the concept was
Goel Neha, Gupta Indivar, Dass B. K.
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Use of ID-Based Cryptography for the Efficient Verification of the Integrity and Authenticity of Web Resources

, 2009
As the amount of information resources on the Web keeps increasing so are the concerns for information integrity, confidentiality and authenticity. In Web 2.0 users are producers as well as consumers of content and metadata, which makes guaranteeing the ...
Tiropanis, Thanassis, Dimitriou, Tassos
core   +2 more sources

Quantum Key Distribution for V2I communications with software‐defined networking

IET Quantum Communication
The evolution of Connected and Autonomous Vehicles (CAVs) promises improvements in our travel experience and the potential to enhance road safety and reduce environmental impact.
Alexandros Stavdas, Evangelos Kosmatos, Carsten Maple, Emilio Hugues‐Salas, Gregory Epiphaniou, Daniel S. Fowler, Shadi A. Razak, Chris Matrakidis, Hu Yuan, Andrew Lord   +9 more
doaj   +1 more source

IMPLEMENTATION OF BLOM’S KEY PREDISTRIBUTION SCHEME BY USING ELLIPTIC CURVE CRYPTOGRAPHY

Malaysian Journal of Computing, 2021
Cryptography, along with its various methods is used to serve the security communication purpose. Cryptography is said to be secure if the encryption key is hard to break by the attacker.
Md Nizam Udin, Farah Azaliney Mohd Amin, Aminah Abdul Malek, Nur Annisa Zulkifili, Nur Atiqah Ghazali, Siti Aisyah Mohd Ridzuwan   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tensor-based trapdoors for CVP and their application to public key cryptography [PDF]

, 1999
We propose two trapdoors for the Closest-Vector-Problem in lattices (CVP) related to the lattice tensor product.
Jean-Pierre Seifert, Fischlin, Roger, Roger Fischlin, Seifert, Jean-Pierre   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source