Results 51 to 60 of about 12,766 (251)

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Quantum Random Oracle Model for Quantum Public-Key Encryption

open access: yesIEEE Access, 2019
Random oracle model is a general security analysis tool for rigorous security proof and effective cryptographic protocol design. In the quantum world, the attempts of constructing a quantum random oracle (QRO) have been made, such as quantum-accessible ...
Tao Shang, Ranyiliu Chen, Qi Lei
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Poly-Dragon: an efficient multivariate public key cryptosystem

open access: yesJournal of Mathematical Cryptology, 2011
In this paper, we propose an efficient multivariate public key cryptosystem. Public key of our cryptosystem contains polynomials of total degree three in plaintext and ciphertext variables, two in plaintext variables and one in ciphertext variables ...
Singh Rajesh P., Saikia A., Sarma B. K.
doaj   +1 more source

Forward-Secure Public-Key Encryption Scheme Based on SM9 [PDF]

open access: yesJisuanji kexue yu tansuo
In the traditional hybrid cryptosystem, an attacker can generate the previously used session key to decrypt session contents encrypted under the session key due to the leakage of the current private key.
HUANG Wenfeng, XU Shengmin, MA Jinhua, NING Jianting, WU Wei
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

New security notions and relations for public-key encryption

open access: yesJournal of Mathematical Cryptology, 2012
Since their introduction, the notions of indistinguishability and non-malleability have been changed and extended by different authors to support different goals.
Sepahi Reza   +3 more
doaj   +1 more source

Dynamic Threshold Public-Key Encryption [PDF]

open access: yes, 2008
This paper deals with threshold public-key encryption which allows a pool of players to decrypt a ciphertext if a given threshold of authorized players cooperate. We generalize this primitive to the dynamic setting, where any user can dynamically join the system, as a possible recipient; the sender can dynamically choose the authorized set of ...
Delerablée, Cécile, Pointcheval, David
openaire   +2 more sources

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