Results 101 to 110 of about 14,820,986 (315)

Keynote address: The action learning, action research experiences of professionals

, 2019
This keynote relates the experiences of professional educational-practitioners, which contribute to the legacy of action learners, action researchers, and others concerned with transforming social change for the flourishing of humanity.
Whitehead, Jack
core  

Coalitions and Public Action in the Reshaping of Corporate Responsibility: The Case of the Retail Banking Industry. [PDF]

J Bus Ethics, 2021
de la Cuesta-González M, Froud J, Tischer D.   +2 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Reflecting on the arts in social action: possibilities for creative engagement in action learning

, 2014
Using my own experience in integrating the arts and Action Learning, I discuss creative expression as a principal strategy in fostering social change and in advancing social betterment.
Moxley, David
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Using Action Research to develop a market orientation in an Australian government business enterprise

, 2016
This article describes an action research study I conducted in an Australian government business enterprise (GBE), with the twin aims of changing the organisational culture towards a market orientation and using this research for a doctoral thesis.
Kalendra, Diane Robyn
core  

Ideational factors associated with appropriate care-seeking for fever among caregivers of children under five years of age: a multi-country analysis in sub-Saharan Africa

Malaria Journal
Background With an estimated 247 million cases and 619,000 deaths reported worldwide in 2021, malaria remains a major cause of morbidity and mortality. The World Health Organization (WHO) Africa region accounts for most cases and deaths.
Albert Casella, Michael Bride, Gabrielle C. Hunter, Michael Toso, Grace N. Awantang, Alain K. Koffi, Jayme Hughes, Thérèse Bleu, Bolanle Olapeju, Abdul Dosso, Florence Mpata, Eric Sompwe Mukomena, Stella Babalola   +12 more
doaj   +1 more source

The effectiveness of treatment for Severe Acute Malnutrition (SAM) delivered by community health workers compared to a traditional facility based model

BMC Health Services Research, 2018
Background In most health systems, Community Health Workers (CHWs) identify and screen for severe acute malnutrition (SAM) in the community. This study aimed to investigate the potential of integrating SAM identification and treatment delivered by CHWs ...
J. L. Alvarez Morán, G. B. Franck Alé, P. Charle, N. Sessions, S. Doumbia, S. Guerrero   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source