Results 111 to 120 of about 5,193,344 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Viewers like you: community norms and contributions to public broadcasting [PDF]
The logic of collective action (Olson 1965) suggests that public broadcasting may be underprovided, because non-contributors are not excluded from receiving the benefits. Why do so many individuals voluntarily contribute to public television, even though
Knack, Stephen, Kropf, Martha
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Ecoso exchange newsletter 2/5; Aug. 1989 [PDF]
, 1989 In this Issue: Pages: 1. Cluster and Connect - The Nunawading Energy Study 3. 2020. A Sustainable Healthy Futures 4. Question of Greenhouse - Public Health Association 5. Rainbow Sustainable Society Seminar - Two Scenarios 5.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Australian and New Zealand Journal of Public Health, 2016 Objectives: To estimate: 1) daily energy deficit required to reduce the weight of overweight children to within normal range; 2) time required to reach normal weight for a proposed achievable (small) target energy deficit of 0.42 MJ/day; 3) impact that ...
Thomas Cochrane +2 more
doaj +1 more source
The New Governance and the Tools of Public Action: An Introduction [PDF]
, 2011 A fundamental re-thinking is currently underway throughout the world about how to cope with public problems. Stimulated by popular frustrations with the cost and effectiveness of government programs and by a new-found faith in liberal economic theories,
Salamon, Lester M.
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Salmon action plan: River Kent, July 2001 [PDF]
, 2001 The report presents the Environment Agency's 5 year Salmon Action Plan for the River Kent for the period from January 2001, providing the background to the plan, responses to the public consultation given, and proposed ...
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source