Results 51 to 60 of about 5,156,945 (309)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Public sector employment in Scotland [June 2012] [PDF]

, 2012
Industrial action over proposals to change pension and related conditions continued in the public sector and widened with industrial action planned by the BMA.
Lockyer, Cliff
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Feasibility of caregiver-administered anthropometric measurements of children under age 5: evidence from Zambia

Population Health Metrics
Background Accurate measurement of children’s anthropometry is of central importance for the assessment of nutritional status as well as for the evaluation of nutrition-specific interventions.
Günther Fink, Mpela Chembe, Savanna Henderson, Peter C Rockers, Doug Parkerson   +4 more
doaj   +1 more source

Health care utilisation in Cox’s Bazar district, Bangladesh, during the first year of the COVID-19 pandemic: A mixed-methods study among host communities

Global Public Health
To respond to the COVID-19 pandemic, countries introduced public health and social measures that had indirect societal, economic consequences. Concerns during epidemics include continuity of routine health services.
Chiara Altare, Natalya Kostandova, Md Abul Hasan, Jogie Abucejo Agbogan, Md Lalan Miah, Hannah Crockett, Madison Bates, Sharon Leslie, Brigitte Tonon, Caroline Antoine, Paul Spiegel   +10 more
doaj   +1 more source

Reinventing Media Activism: Public Interest Advocacy in the Making of U.S. Communication-Information Policy, 1960-2002 [PDF]

, 2004
This report is a long-term analysis of citizens' collective action to influence public policy toward communication and information. The work discusses in greater detail what is meant by communication and information policy (CIP) and why we think it is ...
Brenden Kuerbis, Christiane Page, Milton Mueller   +2 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

On Public Action

Critical Horizons, 2013
AbstractThis essay explores Hannah Arendt’s contribution to our understanding of the rhetorical as opposed to the aesthetic quality of public speech, with an emphasis upon her conception of opinion and glory. Arendt’s focus on the revelatory quality of public action in speech is widely understood to preclude or seriously limit its communicative aspect.
openaire   +4 more sources

The Modified Dosages for Acute Malnutrition (MODAM) study: protocol for three integrated randomized controlled trials of novel approaches for the management of childhood wasting in Ethiopia

BMC Nutrition
Background Only a small percentage of children with severe and moderate acute malnutrition receive treatment due to resource limitations, relatively complex treatment protocols, persistent supply chain challenges, and limited early identification among ...
Indi Trehan, Yosef Beyene, Hiwot Darsene, Bailey S. Adams, Maria Wrabel, Getu Gizaw, Liya A. Legese, Bernardette Cichon, Stanley Chitekwe, Mesfin W. Shellemew, Masresha Tessema, Heather C. Stobaugh   +11 more
doaj   +1 more source

The HIV infection healthcare services continuity in the COVID-19 pandemic context: A mixed cross-sectional analysis of associated determinants in Senegal, 2020–2021

The Microbe
COVID-19 pandemic favoured concentration on its response to the detriment of routine services, such as people living with HIV (PLHIV) follow-up, hence the major services discontinuity risk. Thus, Senegalese National Epidemic Management Committee aimed to
Ibrahima Mamby Keita, Mamadou Makhtar Mbacke Leye, Ndeye Mareme Sougou, Boly Diop, Khaly Gueye, Amsatou Samb, Mansanou Fall, Moussa Ba, Bassirou Sarr, Mouhamadou Fallilou Seck, Mame Fatou Mbodj, Sophie Anna Diandy, Vincent Ahmed Gomis, Serigne Abdou Seck, Djibril Barry, Elhadji Mamadou Ndiaye   +15 more
doaj   +1 more source