Results 131 to 140 of about 10,798,625 (391)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

The role of human resource practitioners in dealing with mental health issues in the workplace Post-COVID-19

open access: yesRUDN Journal of Public Administration
The existence of a worldwide mental health pandemic can no longer be overlooked according to the World Health Organization. Because of the tremendous stigma associated with mental illness, most research done to date has focused on the detrimental ...
Magatane T. Mashilo   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Sociocultural constants as a determinant in the ideological structuring and conceptualization of moderate conservatism in Russia

open access: yesRUDN Journal of Public Administration
The formation of conservative values in Russia has deep historical and cultural roots tied to the evolution of traditional values, cultural constants, institutional transformations, and cognitive shifts. The relevance of this study stems from the growing
Aleksandr V. Protsenko   +1 more
doaj   +1 more source

A human resource management review on public management and public administration research: stop right there…before we go any further…

open access: yes, 2019
This overview paper focuses on the increased popularity of human resource management (HRM) in public management and public administration research. This is reflected in empirical articles published in scientific journals linked to HRM, public management ...
Paul Boselie   +2 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The phenomenon of the global city-state in world politics

open access: yesRUDN Journal of Public Administration
Singapore is the only city-state in the world that has successfully formed the infrastructure and prerequisites for active involvement in global transnational flows, which allows it to be interpreted as a global city-state, which determines the relevance
Maksim I. Kolykhalov
doaj   +1 more source

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