Results 51 to 60 of about 19,606 (282)

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

An emerging framework for fully incorporating public involvement (PI) into patient-reported outcome measures (PROMs)

Journal of Patient-Reported Outcomes, 2020
Patient-reported outcome measures (PROMs) are widely used in the United Kingdom (UK) and internationally to report and monitor patients’ subjective assessments of their symptoms and functional status and also their quality of life.
J. Carlton, T. Peasgood, S. Khan, R. Barber, J. Bostock, A. D. Keetharuth   +5 more
doaj   +1 more source

Supporting patient and public involvement in industry-led research: guidance for charities [PDF]

, 2019
This guidance has been developed by the Charities Research Involvement Group in collaboration with the Health Research Charities Ireland. It aims to help charities in the UK and the Republic of Ireland to promote and support patient and public ...
Ratcliffe, Natasha, Hamilton, Jamie, Kennan, Avril, Kenny, Lorcan, Robertson, Jenny, Smith, Anna-Louise, Allen, Lorna, Nolan, Claire, Hanley, Bec, Wijnbladh, Caroline   +9 more
core   +1 more source

“All Together”: A Case Study Demystifying Patient and Public Involvement (PPI) in Brief Psychological Interventions within a Community Mental Health Service for Adults in the UK [PDF]

The importance and value of involving patients and the public in the decision-making processes within services designed to support them, and research projects aimed at understanding and improving those services, have long been established.
Casey, Stephanie, Xie, Alice, Parkin, Katherine, Chang, Mu-Yin, Maciag, Rachel, Kim, Youngsuk, Nadel, Molly H.   +6 more
core   +1 more source

Patient and public involvement in primary care research - an example of ensuring its sustainability [PDF]

, 2016
BackgroundThe international literature on patient and public involvement (PPI) in research covers a wide range of issues, including active lay involvement throughout the research cycle; roles that patients/public can play; assessing impact of PPI and ...
Dziedzic, Jinks
core   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Involving a black woman patient and public involvement group in maternal health methodology research: learning from the PROMISE Study

Research Involvement and Engagement
Background Patient and public involvement (PPI) is at the centre of high-quality health research, but PPI representatives are often limited in terms of demographic diversity and are often absent from methodology research.
Sophie S. Hall, Georgia Clancy, Shireen Patel, Bhuvan Majmudar, Fatou Benga, Makini Jones, Catherine Henshall   +6 more
doaj   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Patient and public involvement in the design of an international clinical trial: real world experience

Research Involvement and Engagement
Background The value of patient and public involvement (PPI) during the earliest stages of clinical trial development, and prior to the award of substantive funding, is widely recognised. However, it is often under-resourced and PPI processes during this
Gwenda Simons, Helen Jones, Ian Clarke, Firoza Davies, Stacey Grealis, Elspeth Insch, Hameed Kahn, Joanne Lloyd, Al Richards, Hayley Rose, Ruth Williams, Maarten de Wit, Clarissa Woodcock, Leigh Romaniuk, Michelle Bardgett, Arthur G. Pratt, Marie Falahee   +16 more
doaj   +1 more source

Exploring stroke survivor and employer experiences of disruption within the RETurn to work After stroKE (RETAKE) trial during the COVID-19 pandemic

Frontiers in Sociology
IntroductionReturning to work is a goal for many stroke survivors, with benefits for individuals and society. The ReTurn to work After stroKE (RETAKE) trial, which aimed to improve stroke survivors’ work outcomes through early stroke-specific vocational ...
Diane Trusson, Katie Powers, Kate Radford, Kate Radford, Audrey Bowen, Kristelle Craven, Amanda Farrin, Christopher McKevitt, John Murray, Julie Phillips, Judith Stevens, David Clarke   +11 more
doaj   +1 more source