Results 91 to 100 of about 2,567,640 (311)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Religious Authority in Public Spaces: The Challenge of Jurisdictional Pluralism [PDF]

, 2017
The new significance of religion in Australian politics raises serious questions about how our politics is conceived and conducted. Liberal theorists have proposed three successive approaches to resolving the problem of religious disagreement in a ...
Aroney, Nicholas
core   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Improvement of Coordination of Public Authority and Local Authority in Moscow

RUDN Journal of Political Science, 2008
In the article is analyzed the effectiveness of local self-management in Russia. The author ties the level of effectiveness of self-management with coordination of public authority and the bodies of municipal self-management.
V S Bautdinova
doaj  

The first possible case of airport Zika virus infection in the EU/EEA

Travel Medicine and Infectious Disease
Since 2019, when the first autochthonous cases of ZIKV disease were observed in EU/EEA countries, no other locally acquired ZIKV disease cases have been reported in EU/EEA.Our case of ZIKV disease in 2024 had a history of flying from Slovakia to Italy ...
Jana Kerlik, Ján Hockicko, Mária Avdičová, Monika Musilová, Veronika Tarkovská, Elena Tichá, Hana Zelená   +6 more
doaj   +1 more source

Public Authorities in Underdeveloped Countries

Law and Contemporary Problems, 1961
I. Enterprise and Development The non-communist underdeveloped countries provide an extraordinarily rich but as yet poorly-exploited field for the comparative study of public enterprise. It is not that they have shown any special capacity for institutional invention; on the contrary, the forms of public enterprise they have adopted are invariably ...
openaire   +2 more sources

The Key Authority - Secure Key Management in Hierarchical Public Key Infrastructures

, 2004
We model a private key`s life cycle as a finite state machine. The states are the key`s phases of life and the transition functions describe tasks to be done with the key.
Karatsiolis, V., Lippert, M., Wiesmaier, A.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Influence of Altitude, Urbanization, and Local Vaccination Centers on Vaccine Uptake within an Italian Health District: An Analysis of 15,000 Individuals Eligible for Vaccination

Vaccines
In Italy, free vaccinations for Herpes Zoster (HZ), pneumococcal (PCV), and influenza (FLU) are recommended each year for individuals turning 65. Despite this, achieving optimal vaccination coverage remains challenging. This study assesses coverage rates
Andrea Ceccarelli, Giorgia Soro, Chiara Reali, Emilia Biguzzi, Roberta Farneti, Valeria Frassineti, Raffaella Angelini, Gian Luigi Belloli, Davide Gori, Marco Montalti   +9 more
doaj   +1 more source