Results 101 to 110 of about 12,265,777 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
South Carolina Public Service Authority“Santee Cooper” [PDF]
The following presentation is provided for general informational purposes by the South Carolina Public Service Authority (the “Authority” or “Santee Cooper”).
South Carolina Public Service Authority +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Improvement of Coordination of Public Authority and Local Authority in Moscow
RUDN Journal of Political Science, 2008 In the article is analyzed the effectiveness of local self-management in Russia. The author ties the level of effectiveness of self-management with coordination of public authority and the bodies of municipal self-management.
V S Bautdinova
doaj
Annual financial report of the Texas Public Finance Authority documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas Public Finance Authority
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
User satisfaction with health services and healthcare delivery in Cape Verde
BMC Health Services ResearchBackground The evaluation of health services and care is an important tool to define health policies. This study aimed at assessing user satisfaction with healthcare services, provided by public and private health facilities in Cape Verde.
Maria da Luz Mendonça +8 more
doaj +1 more source
The first possible case of airport Zika virus infection in the EU/EEA
Travel Medicine and Infectious DiseaseSince 2019, when the first autochthonous cases of ZIKV disease were observed in EU/EEA countries, no other locally acquired ZIKV disease cases have been reported in EU/EEA.Our case of ZIKV disease in 2024 had a history of flying from Slovakia to Italy ...
Jana Kerlik +6 more
doaj +1 more source
Public Authorities in Underdeveloped Countries
Law and Contemporary Problems, 1961 I. Enterprise and Development The non-communist underdeveloped countries provide an extraordinarily rich but as yet poorly-exploited field for the comparative study of public enterprise. It is not that they have shown any special capacity for institutional invention; on the contrary, the forms of public enterprise they have adopted are invariably ...
openaire +2 more sources