Results 121 to 130 of about 12,265,777 (308)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Predicting patient risk of leaving without being seen using machine learning: a retrospective study in a single overcrowded emergency department

BMC Emergency Medicine
Emergency department (ED) overcrowding has become a critical issue in hospital management, leading to increased patient wait times and higher rates of individuals leaving without being seen (LWBS). This study aims to identify key factors influencing LWBS
Arianna Scala, Teresa Angela Trunfio, Massimo Majolo, Michelangelo Chiacchio, Giuseppe Russo, Paolo Montuori, Giovanni Improta   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Qualitative study investigating the health needs of school-aged children and adolescents in Dubai

BMJ Open
Background Children’s health has been linked with morbidities such as cardiovascular events, type 2 diabetes and obesity in adulthood. Further efforts are needed to understand the current and emerging challenges due to the potential changes in the social
Ali Muneer Alrahma, Sana Easa Belal, Fatima Hassan Mohamed Koko, Kadhim Alabady   +3 more
doaj   +1 more source

Royal Religious Authority: Morocco’s "Commander of the Faithful"

, 2019
King Mohammed VI of Morocco has cultivated the country’s image as a bastion of moderate Islam and of himself as a strategic partner, but to what extent does his international reputation correspond to public opinion in Morocco?
Sheline, Annelle R.
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Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Inside Oregon Youth Authority

, 2010
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Began with Jan. 2010Mode of access: Internet from the Oregon

core  

Renewable Energy Target review [PDF]

, 2014
SUMMARY This is the Climate Change Authority\u27s second review of the Renewable Energy Target (RET). The RET targets reductions in greenhouse gas emissions from the electricity sector and thereby contributes significantly to reducing Australia\u27s ...
Climate Change Authority
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Nesmeyanova S.E. Levels (centers) of public authority: modern interpretation of theory and practice

Правоприменение
The subject of the study is the legal relations arising from the public authority’s organization and its levels’ interaction after the constitutional reform of 2020. The organized interaction of the public authority levels determines the effectiveness of
A. V. Bleshchik, A. G. Kalinina, S. E. Nesmeyanova   +2 more
doaj   +1 more source