Results 111 to 120 of about 2,587,050 (312)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Predicting patient risk of leaving without being seen using machine learning: a retrospective study in a single overcrowded emergency department

BMC Emergency Medicine
Emergency department (ED) overcrowding has become a critical issue in hospital management, leading to increased patient wait times and higher rates of individuals leaving without being seen (LWBS). This study aims to identify key factors influencing LWBS
Arianna Scala, Teresa Angela Trunfio, Massimo Majolo, Michelangelo Chiacchio, Giuseppe Russo, Paolo Montuori, Giovanni Improta   +6 more
doaj   +1 more source

Effectiveness of a mRNA Vaccine Booster Dose Against COVID-19 Among Oregon Healthcare Personnel, January 2021-June 2023

Antimicrobial Stewardship & Healthcare Epidemiology
Background: The prioritization of U.S. health care personnel (HCP) for early receipt of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) allowed for the evaluation of the effectiveness of these vaccines ...
Madysen Schreiber, Eric Hall, Valerie Ocampo, Alexia Zhang, Angela Dusko   +4 more
doaj   +1 more source

Personalized Genetic Testing and Norovirus Susceptibility

Canadian Journal of Infectious Diseases and Medical Microbiology, 2014
BACKGROUND: The availability of direct-to-consumer personalized genetic testing has enabled the public to access and interpret their own genetic information.
Natalie Prystajecky, Fiona SL Brinkman, Brian Auk, Judith L Isaac-Renton, Patrick Tang   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CANCER, PUBLIC AUTHORITIES, AND THE PUBLIC [PDF]

BMJ, 1914
openaire   +3 more sources

Qualitative study investigating the health needs of school-aged children and adolescents in Dubai

BMJ Open
Background Children’s health has been linked with morbidities such as cardiovascular events, type 2 diabetes and obesity in adulthood. Further efforts are needed to understand the current and emerging challenges due to the potential changes in the social
Ali Muneer Alrahma, Sana Easa Belal, Fatima Hassan Mohamed Koko, Kadhim Alabady   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Incidence and trends of adverse drug reactions during seasonal malaria chemoprevention among children: evidence from Ghana’s pharmacovigilance database, 2015–2023

Malaria Journal
Background Seasonal Malaria Chemoprevention, which involves giving sulphadoxine–pyrimethamine and amodiaquine (SPAQ) to children aged 3–59 months, is a key strategy for preventing malaria in Ghana.
Benjamin Akwasi Forkuo Otoo, Michael Opoku-Mireku, Seth Kwaku Seaneke, Delese Mimi Darko, George Tsey Sabblah, Harriet Affran Bonful   +5 more
doaj   +1 more source

Political Constraints and Public Support for Market Reform [PDF]

As concerns of "reform fatigue" in lower- and middle-income countries have become more widespread, so has the search for ways of boosting support for market-oriented reforms.
Anders Olofsg�rd, Raj M. Desai
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