Results 71 to 80 of about 2,254,914 (312)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Preference variation in volunteering decisions: public goods and private benefits [PDF]

open access: yes
We use data from the Survey of Health, Ageing and Retirement in Europe (SHARE) to explain the amount of time invested in volunteering in eight European countries.
Bert WEEMAES, Erik SCHOKKAERT
core   +3 more sources

Applying Intermediate Microeconomics to Terrorism [PDF]

open access: yes
The authors show how microeconomic concepts and principles are applicable to the study of terrorism. The utility maximization model provides insights into both terrorist resource allocation choices and government counterterrorism efforts, while basic ...
Charles Anderton, John Carter
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Microeconomic Models of Overlapping Competing Jurisdictions (FOCJs)

open access: yesEesti Majanduspoliitilised Väitlused, 2017
One of the newer suggestions for the design of public economic units refers to Functional Overlapping Competing Jurisdictions (FOCJs), which are instruments to shape cooperation of jurisdictions, e.g. municipalities.
Mariia Chebotareva, Peter Friedrich
doaj   +1 more source

Fair Shares for All? The development of needs based governmental funding in education, health and housing [PDF]

open access: yes
Furthering equity as an achievable public policy objective is based on the ability to assess needs accurately, and distribute resources accordingly. This paper plots the development of the formulae governing resouce allocation in education, health and ...
Ross Hendry
core  

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

How democracy resolves conflict in difficult games [PDF]

open access: yes
Democracy resolves conflicts in difficult games like Prisoners’ Dilemma and Chicken by stabilizing their cooperative outcomes. It does so by transforming these games into games in which voters are presented with a choice between a cooperative outcome and
Brams, Steven J., Kilgour, D. Marc
core   +1 more source

Una teoría de las instituciones y procesos políticos metodológicamente individualista: el programa de investigación de la escuela de la Public Choice [PDF]

open access: yes, 1990
The Methodological Individualism in a Theory of Political Institutions and Processes: The Public Choice Research Programm. In the present paper a positive analysis is developed of one of the methodological foundations of public choice Theory or research ...
Toboso, Fernando
core   +2 more sources

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