Results 31 to 40 of about 17,310 (256)

Boundary Objects and Public Deliberation: Analyzing the Management of Boundary Tensions in the Consensus Conference

open access: yesJournal of Deliberative Democracy, 2013
Consistent with studies on inclusive management, this paper adopts the concept of “boundary object” and therefore an emergent approach to explain the collaboration of heterogeneous social actors in public deliberation.
Hsin-Yi Yeh
doaj   +2 more sources

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba   +11 more
wiley   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt   +76 more
wiley   +1 more source

Everyday Epistemologies: What People Say About Knowledge and What It Means for Public Deliberation

open access: yesJournal of Deliberative Democracy, 2019
Public knowledge presents a persistent problem for democratic deliberation. While especially salient for public participation in technical decision-making, scholars agree that all deliberations are best informed by quality, shared information.
Colene J. Lind
doaj   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

A New Purpose for International Broadcasting: Subsidizing Deliberative Technologies in Nontransitioning States

open access: yesJournal of Deliberative Democracy, 2012
In failed or failing states, deliberation as it is operationalized in much of the political communication literature is inapplicable. These states lack advanced communication infrastructures, press systems and public spheres, which require high literacy ...
Shawn M. Powers, William Youmans
doaj   +2 more sources

The Discursive Functions of Deliberative Voting

open access: yesJournal of Deliberative Democracy, 2022
This study aims to build on Moore and O'Doherty's (2014) proposal to integrate deliberative voting procedures into deliberative processes. Deliberative voting has been proposed to recognize collective endpoints of deliberation and solicit key reasons ...
Kieran C. O'Doherty, Kristie Serota
doaj   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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