Results 31 to 40 of about 8,868,459 (298)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PUBLIC DOMAIN PROTECTION. USES AND REUSES OF PUBLIC DOMAIN WORKS [PDF]

Challenges of the Knowledge Society, 2015
This study tries to highlight the necessity of an awareness of the right of access to the public domain, particularly using the example of works whose protection period has expired, as well as the ones which the law considers to be excluded from ...
Monica Adriana LUPAȘCU
doaj  

EXCLUSION OF STATE CLAIMS FROM THE SCOPE OF STATUTE OF LIMITATIONS RULES [PDF]

Legal Bulletin
The relevance of the study is determined by the adoption of the Constitutional Court of the Russian Federation Resolution No. 49-P of October 31, 2024, which established that No.
KIRPICHEV A.E.
doaj   +1 more source

Investigating Pathology of Gerontocracy Authority and Civil Authority in Public Domain to Collective Strife Approach (Case Study: Baghmalek City and Ramhormoz City) [PDF]

توسعه اجتماعی, 2018
This paper reviews the authority status with an emphasis on collective strife and it is a descriptive research. Data collection is done by documentary method and to study on100 cases of communal strife as a sample, 40 in Baghmalek and 60 in Ramhormoz ...
manouchehr kord zangeneh
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

CULTURAL HERITAGE AND ITS PROTECTION AS CONTINUATION OF INTELLECTUAL PROPERTY RIGHTS [PDF]

Challenges of the Knowledge Society, 2023
In the public space there is a heated debate about the extension of the public domain with works which are no longer protected through copyright and there are a lot of advocates for this idea, including for the decrease of the duration of protection of ...
Cristiana BUDILEANU
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

BIComun: un experimento en el espacio público / BIComun: an experiment in public space [PDF]

Tejuelo: Didáctica de la Lengua y la Literatura, 2014
Resumen: “BIC, Bien de Interés Cultural, hace referencia a una figura jurídica que aparece en nuestras leyes de Patrimonio...” + “Procomún se define como los bienes que pertenecen a todos, que heredamos, creamos conjuntamente y que queremos entregar a ...
María Masaguer Otero, Adela Vázquez Veiga   +1 more
doaj  

Vers la gestion intégrée des zones côtières en Espagne : état des lieux

VertigO, 2009
The report presented by Spain to the Commission of the European Communities on March 28, 2006 shows some progress in the integrated management of coastal zones while recognizing that the achievement of an effective policy on the matter still encounters ...
José Juste Ruiz
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source