Results 41 to 50 of about 14,096,515 (294)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Les enjeux juridiques liés à la numérisation tridimensionnelle du patrimoine
In Situ, 2020 The digitisation of heritage plays an increasingly important role in cultural institutions such as museums, archives services or libraries, as it lets their traditional missions of conservation and research evolve, and it develops new ways of ...
Samuel Bonnaud-Le Roux
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Novelty Determination Using the Inherency Doctrine
Journal of Intellectual PropertySupreme Court decision 2017Hu1304 has established an inherency doctrine in determining novelty. According to the decision, it is not enough to simply show the possibility or probability that something can be done to show prior art to be the same as the ...
Insu Yang
doaj +1 more source
, 2018 Context: Public health accreditation is an ongoing national movement to improve the quality of public health departments and the public health system in the United States; however, calls have been made for more evidence regarding best practices in the ...
Wharton, M. Kristina +2 more
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
DEVELOPMENT OF SMALL AND MEDIUM-SIZED ENTERPRISES IN THE FIELD OF CREATIVE INDUSTRIES [PDF]
Legal BulletinThe relevance. One of the priority vectors of development of the state’s economic and social policy is the support of small and medium-sized enterprises.
SEMENOVA O.O., TORMOZOVA V.A.
doaj +1 more source
Biodiversity conservation and intellectual property law: A conceptual misunderstanding [PDF]
Anali Pravnog Fakulteta u Beogradu, 2017 The author has set up a thesis on conceptual incompatibility of intellectual property rights and the objectives of the Convention on the protection of biodiversity.
Marković Slobodan
doaj +1 more source