Results 51 to 60 of about 14,096,515 (294)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
TRANSFER OF PROPERTY ASSETS [PDF]
Challenges of the Knowledge Society, 2018 Starting from the current jurisprudence on the transfer of property assets, in this article, using logical interpretation and also comparative analysis, we intend to investigate the conditions under which an asset from the private domain of the state ...
Vasilica NEGRUŢ
doaj
, 2017 Acknowledgments Preface: Comprised of at Least Jelly? 1 Why Intellectual Property? 2 Thomas Jefferson Writes a Letter 3 The Second Enclosure Movement 4 The Internet Threat 5 The Farmers’ Tale: An Allegory 6 I Got a Mashup 7 The Enclosure of Science and Technology: Two Case Studies 8 A Creative Commons 9 An Evidence-Free Zone 10 An Environmentalism for ...
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Copyright and the Value of the Public Domain: an empirical assessment [PDF]
, 2015 This Report is the outcome of a knowledge exchange scheme which brings together academics (from the disciplines of law, media & communication studies, management and economics), policy makers from the Intellectual Property Office (an executive agency of ...
Erickson, Kristofer +10 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
International Journal of the Commons, 2009 The past three decades have witnessed a period of great turbulence in the economies of biological knowledge, during which there has been great uncertainty as to how and where boundaries could be drawn between public or private knowledge especially with ...
Mark Harvey, Andrew McMeekin
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The impact of the human DNA topoisomerase II C-terminal domain on activity [PDF]
, 2008 Background Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes.
West, K.L. +11 more
core +2 more sources