Results 71 to 80 of about 14,096,515 (294)

New directions in European public health research:report of a workshop [PDF]

, 2007
Public health draws from a range of academic disciplines, social, medical and statistical, and answers questions relevant to improving the health of populations.
Álvarez-Dardet, Carlos, Groot, W., Groot, Wim, Alvarez-Dardet, C., Groenewegen, P, Clarke, A, McCarthy, M, Groenewegen, Peter, McCarthy, M., Delnoij, D., Alvarez-Dardet, C, McCarthy, Mark, Groenewegen, Peter P., Groot, W, Sogoric, S, Sogoric, Selma, Delnoij, D, Sogoric, S., Delnoij, Diana, Groenewegen, P., Clarke, Aileen, Clarke, A.   +21 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

BIComun: un experimento en el espacio público / BIComun: an experiment in public space [PDF]

Tejuelo: Didáctica de la Lengua y la Literatura, 2014
Resumen: “BIC, Bien de Interés Cultural, hace referencia a una figura jurídica que aparece en nuestras leyes de Patrimonio...” + “Procomún se define como los bienes que pertenecen a todos, que heredamos, creamos conjuntamente y que queremos entregar a ...
María Masaguer Otero, Adela Vázquez Veiga   +1 more
doaj  

Vers la gestion intégrée des zones côtières en Espagne : état des lieux

VertigO, 2009
The report presented by Spain to the Commission of the European Communities on March 28, 2006 shows some progress in the integrated management of coastal zones while recognizing that the achievement of an effective policy on the matter still encounters ...
José Juste Ruiz
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Human Capital Barriers to Technological Absorption and Innovation by Ethiopia’s Micro and Small Enterprises (MSEs)

The African Journal of Information and Communication, 2015
Ethiopia's private sector is dominated by micro and small enterprises (MSEs), many of them operating informally. Accordingly, a key challenge for the country's science, technology and innovation (STI) policymakers is finding ways to ensure that these ...
Wondwossen Belete
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Ensuring Equitable Access to Heritage: The Need for an International Standard under the Auspices of UNESCO

International Journal of Documentary Heritage
Memory institutions steward the world’s documentary heritage and fulfil the crucial mission of both preserving and making it accessible to the public. Understanding the critical importance of access to heritage in the digital environment, institutions ...
Brigitte Vézina, Dee Harris
doaj   +1 more source

Information society between the Intellectual Property Law and the public domain [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2019
The information society is ambivalent about intellectual property law. On the one hand, it is the result of technological and economic progress that is (to a certain extent) the result of the operation of intellectual property rights.
Marković Slobodan M.
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source