Results 101 to 110 of about 11,927,505 (263)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Pareto meets Olson: A note on Pareto-optimality and group size in linear public goods games [PDF]
In this paper I examine the relationship between Pareto-optimality and group size in linear public goods games or experiments. In particular, I use the standard setting of homogeneous linear public goods experiments and apply a recently developed tool to
Pickhardt, Michael
core
The Role of Prices on Excludable Public Goods [PDF]
When a public good is excludable it is possible to charge individuals for using the good. We study the role of prices on excludable public goods within an extension of the Stern-Stiglitz version of the Mirrlees optimal income tax model.
Blomquist, Sören, Christiansen, Vidar
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The Main Theories of the Provision of Public Goods: History and Modernity
Проблеми сучасних трансформацій. Серія: економіка та управлінняThe article discusses the history and modern theories of public goods provision, which are a key aspect of the socio-economic system of states. Public goods, such as defense, free education, street lighting, and others, are distinguished by the fact ...
З. М. Гасанов
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Costs of taxation and benefits of public goods with multiple taxes and goods [PDF]
The recent public economics literature involves an apparent consensus that income effects reduce the costs of raising revenues and hence increase the desirable level of public good provision.
Anderson, James E., Martin, Will
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COVID-19 and territorial politics: towards a redefinition of Spanish intergovernmental relations?
Regional Studies, Regional ScienceWhen COVID-19 (coronavirus disease 2019) struck Spain, it caused a multidimensional crisis that sparked countless debates on its health, social and political implications.
Jorge Hernández-Moreno +1 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Inducing a Self-Fulfilling Prophecy in Public Goods Games. [PDF]
This study explores how a self-fulfilling prophecy can solve a social dilemma. We ran two experimental treatments, baseline and automata. Both consisted of a finitely repeated public goods game with a surprise restart.
Enrique Fatas +2 more
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