Results 101 to 110 of about 1,451,696 (310)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

What Makes Public History Truly International?

, 2022
Public History and history didactics are two subdisciplines of history that focus on reaching the world outside the academy. Both put an emphasis on “practising” history while at the same time grounding practice on theoretical reflection and empirical ...
Wojdon, Joanna, CAUVIN, Thomas, Zündorf, Irmgard, Evans, Tanya, Perry, Jimena   +4 more
core  

World, Structure and Play: A Framework for Games as Historical Research Outputs, Tools, and Processes

Práticas da História, 2018
The potential of historical digital games as academic research outputs has been discussed by a small but growing number of authors (Clyde et al., Spring, Chapman, Carvalho, etc.).
Robert Houghton
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Entre a memória e o esquecimento: modos de compreender a história

Almanack
Resumo Este artigo busca comentar pontualmente a pesquisa coordenada por João Paulo Pimenta, considerando as relações entre passado e presente e as perspectivas da história pública presentes nessa pesquisa.
Iara Lis Schiavinatto
doaj   +1 more source

Una stagione di fuoco. Fascismo, guerra e Resistenza nel Parmense

E-Review. Rivista degli Istituti Storici dell'Emilia-Romagna in Rete, 2016
Il volume Una stagione di fuoco è il risultato di un lavoro collettivo promosso dal Centro studi movimenti a partire dal 2014. Esso trae origine da Siamo tutti partigiani.
Centro studi movimenti
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

“How a Democratic Country Could Become a Dictatorial Monster”: A Conversation with Volker Kutscher About His Crime Novels, Babylon Berlin, and the Lessons of the Past

International Public History
The German TV series Babylon Berlin is based on the popular crime novels by Volker Kutscher on Weimar Berlin in the 1920s. In this conversation, the author explains his ambitions to make his readers aware how a democracy can change into a dictatorship ...
Hochmuth Hanno
doaj   +1 more source

Oramics to electronica: investigating lay understandings of the history of technology through a participatory project

Science Museum Group Journal, 2014
Oramics to Electronica was a 2011 Science Museum project designed to put the tools of museum participation in the service of research into public history, taking the history of electronic music as our example.
Dr Tim Boon, Merel van der Vaart, Katy Price   +2 more
doaj   +1 more source