Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The legal and institutional framework for the protection of religious rights in Nigeria and the right to wear Hijab in public institutions. [PDF]
F1000Res, 2023 Elikwu CM, Olujobi OJ, Yebisi ET.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Curriculum study of Public Works Management [PDF]
, 1999 CIVINS (Civilian Institutions) Thesis documenthttp://archive.org/details/curriculumstudyo109458180CIVINSU.S.
Ellwood, John M.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Financial-Accounting Approaching of the Incomes from the Retaking of the Subjects at the Level of the Academic Institutions [PDF]
In the last years, the accounting of the public institutions passed through major transformations in the middle of which were the passing from the accounting based on money to the engagement accounting.
Iuliana CENAR
core
Instituições de Suporte, Serviços e Desempenho: um Estudo em Aglomeração Turística de Santa Catarina [PDF]
RAC: Revista de Administração Contemporânea, 2013 The objective of this study was to evaluate clusters of tourism support institutions on the northern coast of the Brazilian state of Santa Catarina state.
Valmir Emil Hoffmann +1 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Predicting strategic change of public research institutions under unstable negative growth [PDF]
The purpose of this paper is to forecast and analyse, by a demographic perspective, the organizational behaviour of public research labs. The research focuses on the biggest Italian public research body.
Mario Coccia
core
Public health training in public institutions' speech-language-hearing programs in Northeastern Brazil: a curricular framework study. [PDF]
Codas, 2023 Silva EMD +6 more
europepmc +1 more source