Results 71 to 80 of about 3,624,559 (303)
Institutional Theories and Public Institutions: New Agendas and Appropriateness
, 2012 This chapter covers the evolution of institutional theory and its application to public adminsitrations in the last 20 years. It discusses the various streams, their reseach agendas and their contributions, but also their limits to add value to knowledge.
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Functional analysis in public sector
Business, Management and Education, 2010 The main aim of the paper is to explore the theoretical aspects of functional analysis on purpose to identify the essence of functional analysis in public sector. This objective was chosen in reference to relevant problem of modern-day, i.e. inefficiency
Živilė Tunčikienė, Giedrė Buzaitė
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Do Historically Black Institutions of Higher Education Confer Unique Advantages on Black Students? An Initial Analysis [PDF]
, 1994 [Excerpt] Despite the declining relative importance of HBIs in the production of black bachelor\u27s degrees, in recent years they have become the subject of intense public policy debate for two reasons.
Ehrenberg, Ronald G, Rothstein, Donna S
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Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Development of eating behavior: the way from infancy to adolescence. Review of foreign studies
Клиническая и специальная психология, 2016 Studies examining development of eating behavior in different age groups are reviewed. Determinants of disordered eating attitudes from infancy to adolescent are particularly examined. Family environment and social context are general factors. Knowledge,
Durneva M.U.
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