Results 101 to 110 of about 2,639,699 (314)

Integração da participação no processo de tomada de decisão referente a projectos de engenharia Integrated participation in decision-making process involving engineering projects

Ambiente & Sociedade, 2006
Os efeitos de ocupação e uso do solo (e.g. intervenções de engenharia) no ambiente e sociedade têm se tornado cada vez mais evidentes, mesmo para o cidadão comum.
Herlander Mata Lima, Lia Vasconcelos
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploring Barriers and Facilitators to Patients and Members of the Public Contributing to Rapid Health Technology Assessments for NICE: A Qualitative Study

Health Expectations
Background Evidence and External Assessment Groups (EAGs) assist in the National Institute of Health and Care Excellence's Technology Appraisal programme by either critiquing evidence provided by companies on different health technologies, or by carrying
Eugenie Evelynne Johnson, Debbie Smith, Becky Harmston, Emily Hunter, Emma Belilios, Fiona Pearson   +5 more
doaj   +1 more source

Public involvement in alcohol research. [PDF]

, 2017
In late 2016, Alcohol Research UK initiated a programme of work exploring public involvement in alcohol research. Over the following months, we ran a series of national events with service providers, research leaders, funding bodies, academics, and ...

core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Researchers' perspectives on public involvement in health research in Singapore: The argument for a community‐based approach

Health Expectations, 2019
Background Singapore is becoming a world‐class research hub, promoting the advancement of patient care through translational clinical research. Despite growing evidence internationally of the positive impact of public involvement (PPI), in Singapore PPI ...
Lidia Luna Puerta, Bernadette Bartlam, Helen E. Smith   +2 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

T022: Sharing decisions regarding radiotherapy for Hodgkin lymphoma: a qualitative study of the experiences of patients and clinicians in the UK

HemaSphere, 2022
Rebecca Shakir, Catriona Gilmour-Hamilton, Craig Bakin, Isabelle Gent, Adam Holloway, Alison Meeson, Johanna Ramroth, Georgios Ntentas, David Cutter, Michele Peters   +9 more
doaj   +1 more source

An AHP-ISM approach for considering public preferences in a public transport development decision

Transport, 2019
Recently, there has been a transparent need to involve public in transport development decisions not only in the EU but also in other countries worldwide. Public involvement in decision-making, however, suffers from two critical issues: lack of expertise
Szabolcs Duleba
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source