Results 81 to 90 of about 725,840 (314)

Embedding Public Involvement in a PhD Research Project With People Affected by Advanced Liver Disease

Health Expectations
Background Liver disease is an increasing cause of morbidity and mortality in the United Kingdom and can be challenging to live with in the advanced stages.
Cathy J. Beresford, Mahabuba Rahman, Yvonne Gray, Sandra Ramshaw, Leslie Gelling, Sue Baron, Jackie Dominey   +6 more
doaj   +1 more source

CP-EXCEL:  A feasibility randomised controlled trial of an online exercise programme for adults with cerebral palsy [version 3; peer review: 2 approved]

HRB Open Research
Introduction Adults with cerebral palsy (CP) are at increased risk of non-communicable diseases and often experience secondary complications as they age. Physical activity can mitigate these risks and improve well-being.
Karen McConnell, Rebecca Walters, Aisling Walsh, Éabha Wall, Claire Kerr, Claire Kenny, Kevin Bravender, Jessica Burke, Rachel Byrne, Jennifer Ryan, Fiona Weldon, Pauline Hunter-Graham, Manjula Manikandan, Miriam Creeger, Ailish McGahey   +14 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

User involvement in a Cochrane systematic review: using structured methods to enhance the clinical relevance, usefulness and usability of a systematic review update [PDF]

, 2015
Background: This paper describes the structured methods used to involve patients, carers and health professionals in an update of a Cochrane systematic review relating to physiotherapy after stroke and explores the perceived impact of involvement.Methods:
Pei Ling Choo, Campbell, P., Morris, J., Morris, Jacqui; id_orcid, Gillian Baer, Morris, Jacqui, Pauline Campbell, Pollock, Alex, Campbell, Pauline, Forster, Anne, Morris, J, Campbell, Pauline; id_orcid, Choo, P-L, Campbell, P, Baer, Gillian, Choo, Pei Ling, Pollock, A., Forster, A., Anne Forster, Baer, Gill, Pollock, A, Alex Pollock, Jacqui Morris, Forster, A   +23 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Innovativeness and consumer involvement in the Chinese market

, 2006
There are many markets where two technologies co-exist and compete and predicting consumer choice in this situation is difficult. Existing theories such as the diffusion of innovation go some way to explaining the initial take up of the new technology ...
Hynes, N., Lo, S., Hynes, Niki
core  

Public Policy in Urban Development: The Privatization of Public Goods in Ciudad Juárez

, 2019
In this research paper, the author explores public policy issues related to the increasing elite involvement in urban development and privatization in Ciudad Juárez ...
Rueda, Lourdes Ampudia
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Public health and public involvement

Critical Public Health, 2008
Involving the public and stakeholders in public health initiatives is so much a routine part of public health that we hardly ever reflect upon it, either as a principle or a process.
openaire   +1 more source