Results 61 to 70 of about 659,515 (266)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Consortium‐Based Patient and Public Involvement and Engagement for Long COVID Research: A Pirit‐Focused Impact Evaluation of the PHOSP‐COVID Study

Health Expectations
Background At the start of the coronavirus disease‐2019 (COVID‐19) pandemic in early 2020, the long‐term outcomes for survivors of COVID‐19 were unknown.
Linzy Houchen‐Wolloff, Joanna Bell, Rebecca Pritchard, Krisnah Poinasamy, Kate Holmes, Samantha Walker, Nikki Smith, Claire Hastie, Natalie Rogers, Dawn Adams, Rashmita Nathu, Rhyan Gill, Jenny Bunker, Lily Staunton, James Chalmers, Ling‐Pei Ho, Victoria Harris, Alexander Horsley, Michael Marks, Betty Raman, Louise V. Wain, Christopher Brightling, Rachael Evans   +22 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Public health and public involvement

Critical Public Health, 2008
Involving the public and stakeholders in public health initiatives is so much a routine part of public health that we hardly ever reflect upon it, either as a principle or a process.
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

“They are nae worrying about it… so …what’s the point in asking?”: A qualitative study of candidacy for early CKD care in areas of multiple deprivation

BMC Nephrology
Background Chronic kidney disease (CKD) is common, associated with substantial comorbidity and strong socioeconomic gradients. Early CKD care focuses on preventing disease progression and reducing cardiovascular risk. However, inequities in access to CKD
Buse Keskindag, Tom Blakeman, Audrey Hughes, Samira Bell, Mike Melvin, Fumiko Nakamaru, Melany Gray, Bhautesh Jani, Mhairi Mackenzie, Nicole Scholes-Robertson, Eilidh Cowan, Paul Cockwell, Simon Sawhney, Magdalena Rzewuska Diaz   +13 more
doaj   +1 more source

The 20 m shuttle run is not a valid test of cardiorespiratory fitness in boys aged 11–14 years

BMJ Open Sport & Exercise Medicine, 2019
Objectives The 20 m shuttle run test (20mSRT) is used to estimate cardiorespiratory fitness (CRF) through the prediction of peak oxygen uptake (V˙O2), but its validity as a measure of CRF during childhood and adolescence is questionable.
Jo Welsman, Neil Armstrong
doaj   +1 more source