Results 121 to 130 of about 2,639,699 (314)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
BMC Palliative CareBackground Deprescribing has been defined as the planned process of reducing or stopping medications that may no longer be beneficial or are causing harm, with the goal of reducing medication burden while improving patient quality of life.
Anna Robinson-Barella +10 more
doaj +1 more source
Lessons learnt from the IWRM demonstration projects: innovations in local-level integrated water resource development in Malawi, Mozambique, Swaziland and Zambia [PDF]
Water resource management / Guidelines / Project planning / Financing / Multiple use / Irrigation water / Domestic water / Participatory management / Community involvement / Empowerment / Local government / Poverty / Public health / Malawi / Mozambique /
Chisaka, J. +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2019 Zoe Rogich and Greg Graves present Meaningful Public Involvement as part of the LAEP Speaker Series.
Rogich, Zoe, Graves, Greg
openaire +1 more source
Musings about involvement in research… [PDF]
, 2015 Almost every research funding application will now have a section asking about involvement, be it “patient and public involvement”, “public involvement” or “user, carer, practitioner involvement”
Blog Admin, LSE Social Care Research Impact Blog
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
What Motivates Youth Civic Involvement? [PDF]
Though the topic of youth civic involvement is increasingly popular in social science research, the question of why some youth are civically involved while others are not is not yet well understood.
Jahromi, Parissa L.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source