Results 121 to 130 of about 2,644,827 (313)

Co-production as the ultimate goal; an incentive or discouragement?

open access: yesResearch Involvement and Engagement
Patient and public involvement (PPI) in research is a requirement in most of the western world. Funders routinely require extensive PPI plans from applicants and co-production is seen as the ultimate goal.
A. Bangiri   +5 more
doaj   +1 more source

Meaningful Public Involvement

open access: yes, 2019
Zoe Rogich and Greg Graves present Meaningful Public Involvement as part of the LAEP Speaker Series.
Rogich, Zoe, Graves, Greg
openaire   +1 more source

Lessons learnt from the IWRM demonstration projects: innovations in local-level integrated water resource development in Malawi, Mozambique, Swaziland and Zambia [PDF]

open access: yes
Water resource management / Guidelines / Project planning / Financing / Multiple use / Irrigation water / Domestic water / Participatory management / Community involvement / Empowerment / Local government / Poverty / Public health / Malawi / Mozambique /
Chisaka, J.   +2 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

“Starting to think that way from the start”: approaching deprescribing decision-making for people accessing palliative care - a qualitative exploration of healthcare professionals views

open access: yesBMC Palliative Care
Background Deprescribing has been defined as the planned process of reducing or stopping medications that may no longer be beneficial or are causing harm, with the goal of reducing medication burden while improving patient quality of life.
Anna Robinson-Barella   +10 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

The rise and fall of the patient forum [PDF]

open access: yes
The circular, ‘A Stronger Local Voice’ (Department of Health 2006) published in July announced that Patient Forums in England will be abolished to be replaced by local authority run Local Involvement Networks (LINks). What went wrong with Forums?
Warwick, Philip
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Who and how should participate in health care priority setting? Evidence from a Portuguese survey [PDF]

open access: yes
This article provides highlights of the evolution of the health care rationing debate towards a more transparent and open approach involving public participation. Discretionary models that have dominated health sector decision-making are being questioned
Anabela Botelho   +2 more
core  

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