Results 71 to 80 of about 2,644,827 (313)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Public involvement in health care
BMJ, 2004 The NHS needs to be clear about the aims and how to achieve them The government is promoting public involvement in health care as part of new NHS policy.1 2 Proposals include allowing the public to elect members of the governing boards of foundation trusts3 and primary care trusts' obligations to engage with the public.4 However, clarity and ...
Dominique, Florin, Jennifer, Dixon
openaire +3 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A REVIEW ON PUBLIC PARTICIPATION IN ENVIRONMENTAL IMPACT ASSESSMENT IN MALAYSIA [PDF]
Environmental Impact Assessment (EIA) was introduced to measure the benefit or cost from physical development to the public and community. In Malaysia, EIA was initiated in 1988 as a mandatory legislative requirement to protect and enhance the quality of
Azizan MARZUKI
core
The Benefits of Campaign Spending [PDF]
, 2003 Critics of American politics often say that spending on electoral campaigns harms our democracy. They charge that the money goes for cynical, negative, and misleading advertisements that alienate the public from politics and elections.
John J. Coleman
core
Can consumer research panels form an effective part of the cancer research community? [PDF]
, 2007 The North Trent Cancer Research Network’s Consumer Research Panel (NTCRN CRP) was established in December 2001 by the Academic Unit of Supportive Care at the University of Sheffield.
Ahmedzai, S. H. +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Health ExpectationsBackground Liver disease is an increasing cause of morbidity and mortality in the United Kingdom and can be challenging to live with in the advanced stages.
Cathy J. Beresford +6 more
doaj +1 more source
Addressing the Intersections of Juvenile Justice Involvement and Youth Homelessness: Principles for Change [PDF]
, 2017 A young person's involvement with the justice system can increase their likelihood of later experiencing homelessness for many reasons, including the fact that educational disruptions and juvenile delinquency records can make it harder to obtain ...
Lisa Pilnik
core
Digital information and the 'privatisation of knowledge' [PDF]
, 2007 Purpose of this paper: To point out that past models of information ownership may not carry over to the age of digital information. The fact that public ownership of information (for example, by means of national and public library collections) created ...
Adobe +8 more
core +1 more source