Results 101 to 110 of about 16,729,036 (330)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Design of CSKAS-VANET model for stable clustering and authentication scheme using RBMA and signcryption

open access: yesFrontiers in Computer Science
A public key infrastructure-enabled system authentication model is developed to provide essential security functions for Vehicular ad hoc networks (VANETs). An intelligent transportation system is provided by VANET, an emerging technology.
M. Gayathri, C. Gomathy
doaj   +1 more source

Computational Thinking Enrichment: Public-Key Cryptography

open access: yesInformatics in Education, 2018
The Computer Science Unplugged activities and project has been an influential STEM (Science, Technology, Engineering & Mathematics) initiative, providing enrichment and teaching activities supporting computational thinking.
Frances ROSAMOND
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

A Matrix Multiplication Approach to Quantum-Safe Cryptographic Systems

open access: yesCryptography
This paper introduces a novel approach based on matrix multiplication in Fpn×n, which enables methods for public key exchange, user authentication, digital signatures, blockchain integration, and homomorphic encryption. Unlike traditional algorithms that
Luis Adrián Lizama-Pérez
doaj   +1 more source

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