Results 31 to 40 of about 332,105 (306)

The Effect of Self-efficiency and Psychological Hardiness on Job Burnout through the Mediating Role of Job Motivation (Study Case: the Employees of Public Libraries of Khuzestan Province) [PDF]

open access: yesتحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2018
Purpose: The aim of this study is to investigate the effect of self-efficiency and psychological hardiness on job burnout through the mediating role of job motivation among the employees of public libraries of Khuzestan province.
Abbas Hosseinzadeh Bandaghiri   +2 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Public Libraries, Children and Young People and Social Exclusion [PDF]

open access: yes, 2000
The paper begins by considering the dimensions of the social exclusion of children and young people, including poverty and its relationship with exclusion from school. It then reviews central initiatives in the area of children’s literacy. The paper then
Vincent, John
core  

Performance Evaluation of Iran’s Province of Golestan Public Libraries, by Balanced Score Card [PDF]

open access: yesتحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2016
Purpose: This study aimed to evaluate the performance of public libraries in Golestan province (Iran) by using Balanced Scorecard (BSC) -a relatively new and multidimensional model to evaluate the holistic performance of organizations- in 2013 ...
maryam babaie-chamazkoti   +1 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Public libraries in Malabar : genesis and development [PDF]

open access: yes, 2009
This paper aims to study the genesis and development of public libraries in Malabar. The library movement in Malabar is part of national movement. It is people's movement.
Azhikodan, Sudha
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Enhancing Digital Information Access in Public Libraries [PDF]

open access: yes, 2006
To explore the impact of public digital library resources on urban residents, to elucidate the current usage patterns of public digital library resources/services and levels of satisfaction with the resources/content in urban digital libraries and make ...
Ayers, Kathleen, Liu, Yan Quan
core  

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