Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The priorities of public libraries at the onset of the third millennium [PDF]
, 2007 Purpose – This paper aims to show the main action areas to which public libraries are devoting their efforts and resources at the onset of the twenty-first century, despite their own particularities and needs.
Pacios Lozano, Ana Reyes
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Social Intelligence of Librarians and its Role in the increase of the Social Responsibility of Libraries: A Case Study of Public Libraries of Markazi Province [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2019 Purpose: The present research aims to explore the role of librarians' social intelligence in increasing the social responsibility of public libraries of Markazi province. Methodology: This is an applied and survey-descriptive research.
Akbar Bahmani, Seyed Mehrdad Seyedin
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Effect of Self-efficiency and Psychological Hardiness on Job Burnout through the Mediating Role of Job Motivation (Study Case: the Employees of Public Libraries of Khuzestan Province) [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2018 Purpose: The aim of this study is to investigate the effect of self-efficiency and psychological hardiness on job burnout through the mediating role of job motivation among the employees of public libraries of Khuzestan province.
Abbas Hosseinzadeh Bandaghiri +2 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Enhancing Digital Information Access in Public Libraries [PDF]
, 2006 To explore the impact of public digital library resources on urban residents, to elucidate the current usage patterns of public digital library resources/services and levels of satisfaction with the resources/content in urban digital libraries and make ...
Ayers, Kathleen, Liu, Yan Quan
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Public libraries in the "age of austerity" : income generation and public library ethos [PDF]
, 2014 A UK-wide survey was conducted using questionaires and interviews into the ethical and professional issues that public librarians faced when considering paid versus free access to services.
Poulter, Alan, Pautz, Hartwig
core +3 more sources