Results 41 to 50 of about 160,935 (258)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Performance Evaluation of Iran’s Province of Golestan Public Libraries, by Balanced Score Card [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2016 Purpose: This study aimed to evaluate the performance of public libraries in Golestan province (Iran) by using Balanced Scorecard (BSC) -a relatively new and multidimensional model to evaluate the holistic performance of organizations- in 2013 ...
maryam babaie-chamazkoti +1 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
AFLI Indicators for Measuring Library Performance: An Analytical Developmental Study
Cybrarians Journal, 2018 The objective of this study is to provide improvement opportunities for the Arab Federation of Libraries and Information (AFLI) indicators to measure library performance.
Emad Abu Eid
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The Role of Rural Public Libraries in Empowering and Developing the Rural Community [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومیPurpose: Despite being mostly small institutions, rural public libraries provide a wide range of services and programs in very different areas of life, including personal education, development of individual and civic skills of all citizens and filling ...
Shiva Yari, Mohammad Amin Bahrami
doaj
Cybrarians Journal, 2009 Libraries and the information services they provide on the Internet face a set of challenges imposed by rapid developments in information technology and remote communications.
Mohamed Helmy
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A Review on the Role of Digital Libraries in Promoting Health Literacy [PDF]
Taṣvīr-i salāmat, 2014 Background and objectives : Considering the importance of public health and its key role in reducing treatment costs, new ways can be established to promote the public health knowledge.
Parvin Abdolahzadeh
doaj