Results 131 to 140 of about 5,101,258 (305)
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
Library Line, Winter 2009/2010
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source