Results 251 to 260 of about 6,827,236 (342)

Evidence of neglect of the elderly in sub-Saharan Africa: a scoping review protocol. [PDF]

BMJ Open
Aboh IK, Odonkor Offei FO, Alhassan A, Akoto-Buabeng W, Amoadu M.   +4 more
europepmc   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Presenting a Framework to Professionalize Health Supply Chain Management. [PDF]

Glob Health Sci Pract
Brown AN, Chovitz B, Dos Santos R, Egharevba M, McHenry B, Meier E, Zwinkels D.   +6 more
europepmc   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Outcomes associated with older patients who present or develop delirium in the emergency department: protocol for a systematic review and meta-analysis. [PDF]

BMJ Open
King S, Uleberg O, Pedersen SA, Bjørnsen LP.   +3 more
europepmc   +1 more source

Local History and the Public Library

, 1944
Nellie Rowe Jones
openalex   +2 more sources

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

A scientific future shared with AI. [PDF]

PLoS Biol
Hoch R, Clarke J.
europepmc   +1 more source

TCMD: A High‐Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio‐Based Resources

Advanced Science, EarlyView.
This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu, Yueyao Wang, Yongming Chen, Yunxia Wang, Shicheng Zhang, Gang Luo, Fuhao Cui, Taisheng Du, Zhidan Liu   +8 more
wiley   +1 more source

A metagenomics survey of viral diversity in mosquito vectors allows the first detection of Sindbis virus in Burkina Faso. [PDF]

PLoS One
Kaboré DPA, Exbrayat A, Charriat F, Soma DD, Sawadogo SP, Ouédraogo GA, Tuaillon E, Van de Perre P, Baldet T, Morel C, Dabiré RK, Gil P, Gutierrez S.   +12 more
europepmc   +1 more source