Results 31 to 40 of about 35,666,240 (266)

Leadership In The Public Library : Case Study In Tenteram City Public Library

Record and Library Journal, 2018
In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader.
Muhammad Irsyad Al Fatih, Luki Wijayanti
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Leadership In The Public Library : Case Study In Tenteram City Public Library

Record and Library Journal, 2017
In the formal and informal organization, it is always found someone who is considered more prominent than others, who then appointed or designated as a leader.
Muhammad Irsyad Alfatih
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Bibliographic information in digital culture: on the discussion problems and the results of the III International Bibliographic Congress

Библиосфера, 2021
The present review and analytical article devoted to the III International Bibliographic Congress provides general information about the most acute problems of modern bibliographic activity and the Congress as a whole, offers points of view on the main ...
A. Е. Guskov, О. N. Zlobinskaya, D. V. Kosyakov, N. К. Lelikova, О. L. Lavrik   +4 more
doaj  

Local studies activity of the central libraries of the Russian Federation subjects on the All-Russian survey data

Библиосфера, 2017
The article represents the survey results of 68 central libraries, and reveals two key aspects of local studies: an attitude to norms formulated by the «Guidelines to Local Studies Activity of the Central Library of a Subject of the RF» (2003), and ...
N. M. Balatskaya, M. B. Martirosova
doaj   +1 more source

Cultural Leagues – Forerunners of Public Libraries in Serbia

Bosniaca, 2020
The establishment of cultural societies and institutions throughout Serbia after the Balkan wars were one of the priorities of the Kingdom of Serbia.
Tamara Malešev, Irena Zečević, Olivera Topalov   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source