Results 41 to 50 of about 5,101,258 (305)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Библиосфера, 2017 The article represents the survey results of 68 central libraries, and reveals two key aspects of local studies: an attitude to norms formulated by the «Guidelines to Local Studies Activity of the Central Library of a Subject of the RF» (2003), and ...
N. M. Balatskaya, M. B. Martirosova
doaj +1 more source
Cultural Leagues – Forerunners of Public Libraries in Serbia
Bosniaca, 2020 The establishment of cultural societies and institutions throughout Serbia after the Balkan wars were one of the priorities of the Kingdom of Serbia.
Tamara Malešev +2 more
doaj +1 more source
The Reader and the Library in the Context of Communication between Science and Society
Библиосфера, 2022 The dissemination of scientific knowledge is one of the urgent social tasks today. As part of the interaction between science and society, representatives of the scientific environment create information content, the dissemination of which becomes the ...
L. K. Kurmysheva +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Библиосфера, 2021 The present review and analytical article devoted to the III International Bibliographic Congress provides general information about the most acute problems of modern bibliographic activity and the Congress as a whole, offers points of view on the main ...
A. Е. Guskov +4 more
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Developing Marketing Strategies for Public Libraries
Marketing Libraries Journal, 2018 The objective of marketing is to demonstrate the unlimited possibilities an institution has to offer to its target audience. For public libraries, this means engaging current and new users to attend programs, use resources and view the library as a ...
Monica Sanchez +1 more
doaj