Results 41 to 50 of about 9,320,919 (411)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

The Reader and the Library in the Context of Communication between Science and Society

open access: yesБиблиосфера, 2022
The dissemination of scientific knowledge is one of the urgent social tasks today. As part of the interaction between science and society, representatives of the scientific environment create information content, the dissemination of which becomes the ...
L. K. Kurmysheva   +2 more
doaj   +1 more source

Theorizing Public Libraries as Public Spheres in Library and Information Science [PDF]

open access: yes, 2020
During the 21st century, library and information scholars have set out to theorize the role of public libraries as public spheres. Most of this research is engaging with Habermas’ early work on the structural transformation of the public sphere. Even though Habermas has continued to develop his theories on the public sphere and deliberative democracy ...
openaire   +3 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Local studies activity of the central libraries of the Russian Federation subjects on the All-Russian survey data

open access: yesБиблиосфера, 2017
The article represents the survey results of 68 central libraries, and reveals two key aspects of local studies: an attitude to norms formulated by the «Guidelines to Local Studies Activity of the Central Library of a Subject of the RF» (2003), and ...
N. M. Balatskaya, M. B. Martirosova
doaj   +1 more source

The Public Library as Resistive Space in the Neoliberal City

open access: yesCity & Community, 2019
With reduced hours, decaying infrastructure, and precariously positioned staff, local public libraries provide much needed services in cities devastated by inequality and slashed safety nets.
S. Aptekar
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Bibliographic information in digital culture: on the discussion problems and the results of the III International Bibliographic Congress

open access: yesБиблиосфера, 2021
The present review and analytical article devoted to the III International Bibliographic Congress provides general information about the most acute problems of modern bibliographic activity and the Congress as a whole, offers points of view on the main ...
A. Е. Guskov   +4 more
doaj  

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