Results 51 to 60 of about 2,015,941 (312)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Digital Authoritarian: On the Evolution and Spread of Toxic Leadership
World, 2023 Employing a critical approach typical of humanities-based research, this article investigates the changing nature of toxic leadership in our digital world.
Brian L. Ott, Carrisa S. Hoelscher
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
COMPARATIVE ANALYSIS OF PUBLIC MANAGEMENT IN ROMANIA AND EU COUNTRIES [PDF]
Annals of the University of Petrosani: Economics, 2013 The paper presents the essential co-ordonates of public management with the view of realization of comparative analysis of manner of carrying on of activities in the field of public management in E.U. countries and in our country.
ANCA JARMILA GUŢĂ
doaj
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Cadernos EBAPE.BREste artigo procura discutir as práticas de gestão associadas ao plano estratégico do município mineiro de Juiz de Fora (PlanoJF). Para tanto, recupera algumas características da intervenção estatal entre as décadas de 1930 e 1980 no Brasil.
Virgílio Cézar da Silva e Oliveira +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Public Service Motivation Research: Achievements, Challenges, and Future Directions
, 2015 This article takes stock of public service motivation research to identify achievements, challenges, and an agenda for research to build on progress made since 1990.
Vandenabeele, Wouter +4 more
core +1 more source