Results 61 to 70 of about 20,571,475 (296)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Analysis of the public entrepreneurship phenomenon in a Brazilian state

open access: yesTourism & Management Studies, 2014
This study examined the role of public entrepreneurs established in a state of Brazil. As our research showed, public entrepreneurs can be considered an innovation in people management in public service.
Magnus Emmendoerfer   +1 more
doaj  

Terceira Vara da Infância e da Juventude de Porto Alegre: um estudo da aplicação da análise administrativa na modernização do Estado 3rd Infancy and Youth Judgeship of Porto Alegre (Brazil): a study on the use of administrative analysis in State modernization

open access: yesRevista de Administração Pública, 2006
Este artigo descreve a experiência de aplicação da ferramenta de análise administrativa na modernização da gestão pública, especificamente na Terceira Vara da Infância e da Juventude da Comarca de Porto Alegre (RS).
Silvia Generali da Costa
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Analysis of the Field of Public Management: A Response to Kelman, Thompson, Jones and Schedler [PDF]

open access: yes, 2014
This essay examines the field of public management as explicated in the dialogue between Kelman, Thompson, Jones and Schedler (2003) and others, from the perspective of the philosophy of science.
Candreva, Philip J.
core   +1 more source

ESTIMATION OF THE ANTI-CRISIS PLAN OF THE RUSSIAN GOVERNMENT FOR 2015 AND MEASURES FOR ITS IMPROVEMENT

open access: yesRussian Journal of Economics and Law, 2015
Objective: to identify weaknesses in the anti-crisis plan, approved by the RF government’s resolution No. 98-R dated 27 January 2015, and to propose measures for their elimination. Method: abstract-logical.
D. V. Manushin
doaj  

Student perspectives about mobile learning initiatives at Open University of Brazil: the mobile phone issue - doi: 10.4025/actascieduc.v32i2.11545

open access: yesActa Scientiarum. Education, 2010
The objectives of this study were to verify if students of Open University of Brazil approve of mobile learning (m-learning) initiatives, to identify the students' perspectives about m-learning, to develop a model of instructional design for m-learning
Otacilio Antunes Santana   +1 more
doaj   +1 more source

Managers and Public Hospital Performance

open access: yesAmerican Economic Review
We study whether the quality of managers can affect public service provision in the context of public health. Using novel data from public hospitals in Chile, we show how the introduction of a competitive recruitment system and better pay for public hospital CEOs reduced hospital mortality by 8 percent.
Muñoz, Pablo, Otero, Cristóbal
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Percepção da avaliação: um retrato da gestão pública em uma instituição de ensino superior (IES) Evaluation perception: a portrait of public management in a higher education institution

open access: yesRevista de Administração Pública, 2010
A avaliação das universidades vem sendo defendida como instrumento necessário para elevar a qualificação institucional, promovendo a melhoria do ensino, da pesquisa, da extensão e de sua gestão.
Jonas Cardona Venturini   +5 more
doaj   +1 more source

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