Results 51 to 60 of about 7,686,922 (303)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The Nature, Scope, and Effects of the Amnesty Laws That Were Applied in the Early Days of the Second Constitutional Revolution (1908-1909)

open access: yesCeza Hukuku ve Kriminoloji Dergisi, 2022
Crime, punishment, execution, and amnesty are terms are as old as human history and represent social and legal phenomena that are causally related. According to the dictionary, amnesty means the forgiveness of crimes.
Aydın Yetkin
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Correlation and meaning of terms «public order», «law and order» and «public safety» [PDF]

open access: yes, 2014
Кобзар О.Ф. Співвідношення та значення понять «громадський порядок», «правопорядок» та «громадська безпека» / Кобзар О.Ф. // Науковий вісник Ужгородського національного університету. Серія: Право. – 2014. – Вип. 29. Ч. 2. Т. 3. – С.
Kobzar, O. F., Кобзар, О. Ф.
core  

American terror:from Oklahoma City to 9/11 and after [PDF]

open access: yes, 2010
Throughout American history, both terrorism and extremism have been constructed, evoked or ignored strategically by the state, media and public at different points, in order to disown and demonize political movements whenever their ideologies and ...
Winter, Aaron
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

EXERCISE WITH BAD FAITH OF SUBJECTIVE CIVIL RIGHTS [PDF]

open access: yesChallenges of the Knowledge Society, 2012
The abuse of rights is qualified as civil offence and it may not be different from that of aquilian responsibility, the purpose of its sanction is to protect the victim and not to punish the author. In the Romanian legal doctrine, the abuse of rights was
NICOLAE GRADINARU
doaj  

Immigration, Statecraft and Public Health:The 1920 Aliens Order, Medical Examinations and the Limitations of the State in England [PDF]

open access: yes, 2016
This article considers the medical measures of the 1920 Aliens Order barring aliens from Britain. Building on existing local and port public health inspection, the requirement for aliens to be medically inspected before landing significantly expanded the
Taylor, Becky
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Childhood maltreatment and aggressive behavior among college students: a serial mediation model of authenticity and alexithymia

open access: yesFrontiers in Psychiatry
IntroductionAggressive behavior among college students is a concerning issue that not only affects the mental health and personal development of those involved but also poses a threat to societal stability.
Jingya Zhou, Meiting Wei, Qing Xie
doaj   +1 more source

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