Results 51 to 60 of about 3,391,421 (303)

Improving contemporary approaches to the master planning process. [PDF]

, 2014
Master-planning has had a strong revival in recent years. However, significant demographic and social changes are on-going amidst the constraints of the current economic stagnation, the policy of reduced public spending and the drive to respond to ...
7Group and Reed B, Adams D, Adams D, Adams D, AlWaer H, AlWaer H, AlWaer H, Ardron R, Barton H, CABE, CABE (Commission for Architecture and the Built Environment), Cooper I, Cooper R, Curwell S, DCLG, DCLG (Department for Communities and Local Government), Deakin M, DeKay M, Egan Sir J, Ellin N, Husam Al Waer, Lawlor D, Lombardi DR, Lucas C, McInroy N, Newman P, PAN83, Roberts P, Sparks L, Trained P, Urban Design Protocol, Urban Task Force   +31 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Enhancing Place Attachment Through Natural Design in Sports Venues: The Roles of Nature Connectedness and Biophilia

Buildings
With the rise of green building and biophilic design, how sports venues enhance users’ place attachment through natural design features has become a critical interdisciplinary research topic in architecture and environmental psychology. This study adopts
Zhihao Zhang, Wenyue Liu, Linkang Du, Lu Ding   +3 more
doaj   +1 more source

The musealisation of the artist's house as architectural project [PDF]

, 2011
Artist’s houses that are opened to the public as museums shift from a private and everyday to a semi-public and institutional functioning. This transformation of an artist’s house into a house-museum might appear as a mere legal issue or as a matter of ...
Liefooghe, Maarten
core  

Optimal Alignments for Designing Urban Transport Systems: Application to Seville [PDF]

, 2019
The achievement of some of the Sustainable Development Goals (SDGs) from the recent 2030 Agenda for Sustainable Development has drawn the attention of many countries towards urban transport networks. Mathematical modeling constitutes an analytical tool
Marseglia, Guido, Medaglia, Carlo Maria, Mesa López-Colmenar, Juan Antonio, Ortega Riejos, Francisco Alonso   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Event-based surveillance during EXPO Milan 2015. Rationale, tools, procedures, and initial results [PDF]

, 2016
More than 21 million participants attended EXPO Milan from May to October 2015, making it one of the largest protracted mass gathering events in Europe.
Bastiampillai, Anan Judina, Caporali, Maria Grazia, Costanzo, Virgilio, Declich, Silvia, Gabrielli, Eugenia, Gramegna, Maria, Linge, Jens P., Manso, Martina Del, Mantica, Eleonora, Napoli, Christian, Piatti, Alessandra, Pompa, Maria Grazia, Riccardo, Flavia, Vellucci, Loredana, Verile, Marco   +14 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Co-creating a tailored public health intervention to reduce older adults’ sedentary behaviour [PDF]

, 2017
Objective: The increasing health care costs associated with an ageing population and chronic disease burden are largely attributable to modifiable lifestyle factors that are complex and vary between individuals and settings.
Chastin, Sebastien F.M., Leask, Calum, Sandlund, Marlene, Skelton, Dawn A.   +3 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source