Results 71 to 80 of about 640,482 (311)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The built environment and place attachment: Insights from Japanese cities

Preventive Medicine Reports
Objective: Place attachment plays an important role in individuals' health and well-being. Understanding the associations between urban design attributes and place attachment can inform strategies to promote place attachment.
Jiuling Li, Mohammad Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi   +10 more
doaj   +1 more source

Public transport design research initiative

, 2007
This paper introduces the first in a developing series of projects run as part of the Public Transport Design Research Initiative developed by Monash University's Faculty of Art & Design and the Institute of transport Studies.
Reidsema, Carl, Coxon, Selby, Richardson, Mark, Allen, Jonathon, Zehner, Robert B., De Bono, Arthur   +5 more
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ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Introducing Design Thinking in Social Innovation and in the Public Sector: a design based learning framework

European Public & Social Innovation Review, 2017
Design Thinking (DT) is becoming a mantra in the different areas of innovation: including SI and Public sector (Manzini&Rizzo, 2011; Deserti&Rizzo, 2015).
Francesca Rizzo,, Alessandro Deserti, , Onur Cobanli   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

PUSAT OLAHRAGA TINJU DI MAKASSAR PENERAPAN ARSITEKTUR FUTURISTIK

Nature: National Academic Journal of Architecture, 2015
Sports boxing center in Makassar will become a place that has full facilities for boxing fans to watch live matches as well as a place for athletes to gain a science of boxing. Activity center boxing as Landmark new in Makassar by applying the concept of
Syamsul Bahri, Taufik Arfan
doaj   +1 more source

Place, pedagogy and play: participation, design and research with children

, 2020
Place, Pedagogy and Play connects landscape architecture with education, psychology, public health and planning. Over the course of thirteen chapters it examines how design and research of places can be approached through multiple lenses – of pedagogy ...

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Linking activity and place attachment dimensions in enhancing the sense of place [PDF]

, 2007
Sense of place definition includes the point where the physical form, activity and meaning are intertwined in the people experience of a place. In urban design and place quality research, much has been discussed on the influence of the physical form ...
Ujang, Norsidah, Dola, Kamariah
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