Results 71 to 80 of about 612,715 (216)

Green planning of public spaces as a way to create a new image of medium-sized cities

Acta Scientiarum Polonorum. Administratio Locorum
Motives: Cities in today’s world are facing demographic challenges, social and economic problems, limited natural resources and the effects of climate change.
Małgorzata Twardzik, Dorota Rynio, Agnieszka Majorek-Gdula   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Role of Urban Design in Enhancing Humanization in Libyan Cities Through Place Making and Developing Public Spaces

PLANARCH - Design and Planning Research
Most countries globally confront the challenge of escalating population densities, accompanied by an increase in private transportation. This phenomenon has led to the degradation of urban environments in these nations, with a severe scarcity of urban ...
Ali Issa, Hosain Bakoosh, Salah Hajısmaıl, Khaled Elfaki   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Bir “Üst Sokak” Önerisinin Tasarım Süreci

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2014
Kamusal alanlar, bireyin ilk mekan algısını belirleyen, mekana dair deneyim ve anıları şekillendiren bir süreci tanımlamaktadır. Bu alanlar, kamu yapıları ve açık alanlar ile birlikte çevre ve sosyal davranışların sürekli etkileşim içinde olduğu ...
Özgür YERLİ, Sinem ÖZDEDE, Sertaç KAYA, Simge ÖZDAL OKTAY, İrfan DURSUN   +4 more
doaj  

Health and wellbeing impacts of housing converted from non-residential buildings: A mixed-methods exploratory study in London, UK

Wellbeing, Space and Society
Housing quality is a determinant of health, wellbeing and inequities. Since 2013, changes to Permitted Development Rights (PDR) allow conversions of non-residential buildings into housing without planning permission in England.
Helen Pineo, Ben Clifford, Max Eyre, Robert W. Aldridge   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predicting the Impact of Urban Development on Locals’ Place Attachment in Peripheral Settlements [PDF]

Urbanism. Arhitectura. Constructii
As urban development reshapes cityscapes, residents in peripheral settlements face challenges in maintaining Place Attachment. This study examines the potential disruption of Place Dependence, Place Identity, and Place Affection—core components of Place ...
Farid Nazaruddin, Purwanita Setijanti, Arina Hayati   +2 more
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The Use of Tactical Urbanism in Urban Public Spaces in The City of Sulaimani as The Case Study

Sulaimani Journal for Engineering Sciences
This paper aims to explore the impact of using tactical urbanism for reviving the urban public space as a place making method in the city of Sulaimani.as part of thesis about tactical urbanism, public areas in Sulaimani have degraded due to rapid ...
Rozh Mohammed Nawzad1, a, *, Prof. Dr. Alan Faraydoon Ali 2, a   +1 more
doaj   +1 more source