Results 81 to 90 of about 3,403,124 (306)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Identifying and Surpassing Contextual Barriers in Cross-Border Research Collaboration: The Case of the Sino-Swedish Project Shanghai Local Interaction Platform [PDF]

open access: yes, 2013
The Swedish advanced knowledge in integrating within a vastly car-oriented transport system a new (or improved) breed of sustainable public transport operations, complemented by the Chinese ability to speedily support urban design innovation that could ...
Nikitas, Alexandros, Rahe, Ulrike
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

PUSAT OLAHRAGA TINJU DI MAKASSAR PENERAPAN ARSITEKTUR FUTURISTIK

open access: yesNature: National Academic Journal of Architecture, 2015
Sports boxing center in Makassar will become a place that has full facilities for boxing fans to watch live matches as well as a place for athletes to gain a science of boxing. Activity center boxing as Landmark new in Makassar by applying the concept of
Syamsul Bahri, Taufik Arfan
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Aquarium in Question. Pushing the limits of the aquatic realm within the urban environment

open access: yesПроект Байкал, 2016
In April 2016, arch out loud announced the winners of the international architectural competition, the task of which was to design NYC AQUARIUM & PUBLIC WATERFRONT. The first place was occupied by NYC AQUATRIUM designed by Italian architects.
Anna Grigorieva
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Systemic Government and the Civil Servant. A New Pattern for Systemic Design

open access: yesFORMakademisk, 2014
This article examines the emerging application of systemic design methodology within government as practiced by the Alberta Public Service in Edmonton, Canada. A case study, from a practitioner’s perspective, for systemic policy design is presented as an
Jonathan A Veale
doaj   +1 more source

Research and Design of Disinfection Equipment for Public Places

open access: yesInternational Journal of Education and Humanities
The starting point of my design is to redesign the existing product based on the post-epidemic era to make different functional definitions and styling changes.The scientific and technical issues, functional layout distribution, target population and usage scenarios were all well thought out before making the choice.Secondly, this paper focuses on the ...
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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