Results 81 to 90 of about 640,482 (311)

Public Diplomacy, Place Branding, and Refugee Settlement [Elektronisk resurs]

open access: yes, 2021
BackgroundNowadays, not only countries but also cities and regions communicate directly with residents in other countries using public diplomacy. Public diplomacy includes all official efforts to convince targeted sectors of foreign opinion to support or
Rauhut Kompaniets, Olga,   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Aquarium in Question. Pushing the limits of the aquatic realm within the urban environment

open access: yesПроект Байкал, 2016
In April 2016, arch out loud announced the winners of the international architectural competition, the task of which was to design NYC AQUARIUM & PUBLIC WATERFRONT. The first place was occupied by NYC AQUATRIUM designed by Italian architects.
Anna Grigorieva
doaj   +1 more source

Research and Design of Disinfection Equipment for Public Places

open access: yesInternational Journal of Education and Humanities
The starting point of my design is to redesign the existing product based on the post-epidemic era to make different functional definitions and styling changes.The scientific and technical issues, functional layout distribution, target population and usage scenarios were all well thought out before making the choice.Secondly, this paper focuses on the ...
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Systemic Government and the Civil Servant. A New Pattern for Systemic Design

open access: yesFORMakademisk, 2014
This article examines the emerging application of systemic design methodology within government as practiced by the Alberta Public Service in Edmonton, Canada. A case study, from a practitioner’s perspective, for systemic policy design is presented as an
Jonathan A Veale
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Art as Contemplative Place, with Reference to Isamu Noguchi's Sited Works [PDF]

open access: yes, 2007
The term contemplative place, a new concept that forms the core of this research is defined as "space where a meaningful sense of calm can be experienced." Contemplative place situates itself as a category of place. M. Auge defines place as that which is
Okashimo, Colin
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Assessing the effectiveness of architectural design communication through public participation methods [PDF]

open access: yes, 2013
The range of communication methods available to architects to present design development has expanded over recent years. With an increase in competition between architectural practices and the resulting reduction in professional fees, it is becoming ...
Messer, Sebastian   +3 more
core  

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