Results 81 to 90 of about 602,630 (265)

Health and wellbeing impacts of housing converted from non-residential buildings: A mixed-methods exploratory study in London, UK

open access: yesWellbeing, Space and Society
Housing quality is a determinant of health, wellbeing and inequities. Since 2013, changes to Permitted Development Rights (PDR) allow conversions of non-residential buildings into housing without planning permission in England.
Helen Pineo   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Predicting the Impact of Urban Development on Locals’ Place Attachment in Peripheral Settlements [PDF]

open access: yesUrbanism. Arhitectura. Constructii
As urban development reshapes cityscapes, residents in peripheral settlements face challenges in maintaining Place Attachment. This study examines the potential disruption of Place Dependence, Place Identity, and Place Affection—core components of Place ...
Farid Nazaruddin   +2 more
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Use of Tactical Urbanism in Urban Public Spaces in The City of Sulaimani as The Case Study

open access: yesSulaimani Journal for Engineering Sciences
This paper aims to explore the impact of using tactical urbanism for reviving the urban public space as a place making method in the city of Sulaimani.as part of thesis about tactical urbanism, public areas in Sulaimani have degraded due to rapid ...
Rozh Mohammed Nawzad1, a, *   +1 more
doaj   +1 more source

Graphic design in public places under digital transformation

open access: yesFrontiers in Humanities and Social Sciences
Today, in the digital transformation, graphic design in public places is facing a series of challenges and problems, and the issue of readability of graphic design has gradually become important. Graphic design in public places needs to take into account the needs of all users, including the elderly and special groups, to ensure that the graphic design
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

The Role of Landscape Architecture in Sustainable Urban Development: Implementation of Universal Design

open access: yesRUAS
Landscape architecture significantly contributes to sustainable development by incorporating universal design principles in the design of public open spaces.
Nahdatunnisa   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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