Results 81 to 90 of about 5,139,772 (404)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

THE ROLE OF PUBLIC PROCUREMENT IN THE DIGITALIZATION OF THE ECONOMY AND IMPLEMENTATION OF ELECTRONIC COMMERCE

Научно-технические ведомости СПбГПУ: Экономические науки, 2020
One of the important directions in digitizing economic processes is the need to introduce modern information technologies and e-commerce systems into the public procurement system.
Muminov Nozim, Zakhirova Gulnora
doaj   +1 more source

A Next-Generation Digital Procurement Workspace Focusing on Information Integration, Automation, Analytics, and Sustainability [PDF]

arXiv, 2023
Recent events such as wars, sanctions, pandemics, and climate change have shown the importance of proper supply network management. A key step in managing supply networks is procurement. We present an approach for realizing a next-generation procurement workspace that aims to facilitate resilience and sustainability.
arxiv  

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Public procurement as a complex object for management accounting in public sector

Економіка, управління та адміністрування, 2020
In connection with the implementation of budget accounting and public procurement according to international standards, the importance of management accounting in the public sector is enhanced.
V.O. Psota
doaj   +1 more source

How 'one-size-fits-all' public works contract does it better? An assessment of infrastructure provision in Italy [PDF]

arXiv, 2023
Public infrastructure procurement is crucial as a prerequisite for public and private investments and for economic and social capital growth. However, low performance in execution severely hinders infrastructure provision and benefits delivery. One of the most sensitive phases in public infrastructure procurement is the design because of the strategic ...
arxiv  

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

Advanced Science, EarlyView.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu, Weichen Xu, Xuexia Shan, Liping Sun, Shuo Liu, Xixi Sun, Shaoyue Li, Xiaodong Hou, Xiaowan Bo, Chengzhong Peng, Bin Huang, Huixiong Xu, Wenwen Yue   +12 more
wiley   +1 more source

Division of Public Procurement Contracts into Lots

Prawo Budżetowe Państwa i Samorządu, 2018
Public procurement is one of the parts of a public finance sector. It includes the specific solutions in the field of public funds spending. The implementation of the EU directives from 2014 to the Public Procurement Law aimed at, among others, ensuring ...
Katarzyna Jurewicz-Bakun, Magdalena Taraszkiewicz   +1 more
doaj   +1 more source

Taking forward public procurement reforms in Ghana [PDF]

, 2006
The construction industry in Ghana, like many others worldwide, has had its fair share of damning independent reviews. Huge and unsustainable foreign debt, excessive budget deficits, huge contractual payment arrears, poor construction performance ...
Anvuur, A, Kumaraswamy, M, Male, S
core  

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source