Results 51 to 60 of about 5,734,629 (315)

Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada

Human Vaccines & Immunotherapeutics, 2022
Between 18 Dec 2017 and 27 June 2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures.
Wallis Rudnick, Sarah Wilson, Jo Ann Majerovich, Michelle Haavaldsrud, Marene Gatali, Cai-Lei Matsumoto, Shelley Deeks   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Process evaluation of a programme to empower community nurse leadership

BMC Nursing, 2021
Background The Nurses in the Lead (NitL) programme consists of a systematic approach and training to 1) empower community nurses in implementing evidence, targeted at encouraging functional activities of older adults, and 2) train community nurses in ...
Ruth G. M. Vogel, Gerrie J. J. W. Bours, Teuni H. Rooijackers, Silke F. Metzelthin, Petra M. G. Erkens, Erik van Rossum, Sandra M. G. Zwakhalen   +6 more
doaj   +1 more source

An outbreak of hepatitis C virus attributed to the use of multi-dose vials at a colonoscopy clinic, Waterloo Region, Ontario

Canada Communicable Disease Report, 2021
Background: Hepatitis C virus (HCV) transmission has been epidemiologically linked to healthcare settings, particularly out-of-hospital settings such as endoscopy clinics and hemodialysis clinics. These have been largely attributed to lapses in infection
Arianne Folkema, Hsiu-Li Wang, Kristy Wright, M Mustafa Hirji, Anton Andonov, Kathryn Bromley, Chad Ludwig, Amy MacArthur   +7 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Individual-level characteristics and geospatial factors associated with cervical cancer screening participation in Alberta, Canada: a population-based cross-sectional study

BMC Public Health
Background Cervical cancer is the fourth most common cancer in women worldwide. Effective primary prevention with human papillomavirus vaccination and secondary prevention with screening can prevent most cervical cancer cases.
Jessica Law, Geneviève Jessiman-Perreault, Amanda Alberga Machado, Linan Xu, Bonnie Chiang, Huiming Yang, Lisa Allen Scott, Rizwan Shahid, Curtis Mabilangan, Alvin Li, Kamala Adhikari, Gary Teare   +11 more
doaj   +1 more source

The welfare state driving “me” and “we” medicine – a critical discourse analysis

New Genetics and Society, 2020
This study explored the relationship between visions of personalized medicine, for-profit companies, and state governance in the context of an ongoing discussion of “me” vs. “we” medicine.
Morten Deleuran Terkildsen, Viola Burau, Ulla Væggemose, Nina Konstantin Nissen   +3 more
doaj   +1 more source

An Essay on the New Public Defender for the 21st Century [PDF]

, 1995
Funding for public defender services is woefully inadequate.
Ogletree, Charles J., Jr.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Case of Japanese Encephalitis with a Fatal Outcome in an Australian Who Traveled from Bali in 2019

Tropical Medicine and Infectious Disease, 2020
A severe case of Japanese encephalitis virus (JEV) infection, resulting in fatality, occurred in an unvaccinated Australian male traveler from Bali, Indonesia, in 2019.
Alyssa T. Pyke, Keat Choong, Frederick Moore, Sanmarié Schlebusch, Carmel Taylor, Glen Hewitson, Jamie McMahon, Neelima Nair, Peter Moore, Mitchell Finger, Peter Burtonclay, Sarah Wheatley   +11 more
doaj   +1 more source