Results 51 to 60 of about 57,639 (264)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The first mile towards access equity: Is on-demand microtransit a valuable addition to the transportation mix in suburban communities?

Transportation Research Interdisciplinary Perspectives
As cities grow, the benefits of living in them are increasingly unequally distributed. USA cities, in particular, have experienced rapid suburbanization of poverty and decreased levels of access to jobs for transit-dependent and vulnerable communities ...
A.M. Liezenga, T. Verma, J.R. Mayaud, N.Y. Aydin, B. van Wee   +4 more
doaj   +1 more source

An Analysis of Public Transit Connectivity Index in Tehran. The Case Study: Tehran Multi-Modal Transit Network

TeMA: Journal of Land Use, Mobility and Environment, 2016
Public transit is a major priority in modern management of large cities and metropolitan areas in particular. Public transit systems in such cities consist of a large number of nodes and lines which are represented by a complex network.
Amir Reza Mamdoohi, Hamid Zarei
doaj   +1 more source

“*I wouldn’t want to get on the bus*”: Older Adult Public Transit Use and Challenges during the COVID-19 Pandemic

Findings, 2020
This paper reports on older adult (65+) public transit users’ experiences during the COVID-19 pandemic, a group more vulnerable to severe illness from the virus.
Lea Ravensbergen, Bruce Newbold
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Routing in stochastic public transit networks

, 2019
OpenAccess Series in Informatics (OASIcs ...
Geissmann, Barbara, Gianinazzi, Lukas
openaire   +4 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

In the context of public pedagogy: Transit

International Journal of Education Through Art, 2018
Abstract I came to Vancouver, Canada as a visiting Ph.D. student to study a/r/tography at the University of British Columbia (UBC). The multinational and multicultural nature of the city of Vancouver became an unexpected learning resource during my stay.
openaire   +3 more sources