Results 71 to 80 of about 57,554 (264)

Routing in stochastic public transit networks

open access: yes, 2019
OpenAccess Series in Informatics (OASIcs ...
Geissmann, Barbara, Gianinazzi, Lukas
openaire   +5 more sources

Access to Public Transit and Its Influence on Ridership for Older Adults in Two U.S. Cities

open access: yesJournal of Transport and Land Use, 2009
Growth in the population of older adults (age 60 and above) in coming years will challenge urban planners and transportation managers to provide travel options that support autonomy.
Daniel Baldwin Hess
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Understanding social media program usage in public transit agencies

open access: yesInternational Journal of Transportation Science and Technology, 2016
Social media has been gaining prominence in public transit agencies in their communication strategies and daily management. This study aims to better understand recent trends in social media usage in public transit agencies, to examine which agencies use
Jenny H. Liu   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Public space in transition

open access: yes, 2022
Teheran-ro in Seoul and Mediaspree area in Berlin are pristine examples for public spaces with a history of rapid change in the context of broader political and economic transitions. Dahae Lee shows that in such a transitional context, the public sector alone is incapable to provide and manage public space.
openaire   +2 more sources

The Impact of Transportation and the Built Environment on Community and Individual Well-Being in the United States

open access: yesUrban Science
This study investigates the effects of transportation, specifically public transit, the built environment, and sociodemographic factors on community quality of life (QOL) and individuals’ overall life satisfaction (OLS) in the United States.
Muhammad Asif Khan   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Nonlinear Effects of the Built Environment on Public Transit and Private Vehicle Mode Choices: A Trip Chain Perspective

open access: yesRedai dili
Public transportation is a vital means to alleviate urban congestion. Despite substantial investments in public transit infrastructure in China, the development of urban public transportation has been unsatisfactory, with many city residents still ...
Liu Chang   +4 more
doaj   +1 more source

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