Results 61 to 70 of about 502,123 (307)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Factors Determining Transit Access by Car Owners: Implications for Intermodal Passenger Transportation Planning [PDF]

, 2013
Although walking is the dominant mode of transportation to transit facilities, there are strong variations by socio-demographics, geography, mode of public transit used and other factors.
Mallon, Y., Thakuriah, P., Tilahun, N.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The first mile towards access equity: Is on-demand microtransit a valuable addition to the transportation mix in suburban communities?

Transportation Research Interdisciplinary Perspectives
As cities grow, the benefits of living in them are increasingly unequally distributed. USA cities, in particular, have experienced rapid suburbanization of poverty and decreased levels of access to jobs for transit-dependent and vulnerable communities ...
A.M. Liezenga, T. Verma, J.R. Mayaud, N.Y. Aydin, B. van Wee   +4 more
doaj   +1 more source

An Analysis of Public Transit Connectivity Index in Tehran. The Case Study: Tehran Multi-Modal Transit Network

TeMA: Journal of Land Use, Mobility and Environment, 2016
Public transit is a major priority in modern management of large cities and metropolitan areas in particular. Public transit systems in such cities consist of a large number of nodes and lines which are represented by a complex network.
Amir Reza Mamdoohi, Hamid Zarei
doaj   +1 more source

Mobility and Equity for New York's Transit-Starved Neighborhoods: The Case for Full-Featured Bus Rapid Transit [PDF]

, 2013
New York City's public transportation system moves millions of people every day. But an increasing number who live in outer borough neighborhoods are stuck with unreliable transit options and long travel times tracked in hours, not minutes.It does not ...
Elena Conte, Joan Byron
core  

Investigating impacts of environmental factors on the cycling behavior of bicycle-sharing users [PDF]

, 2017
As it is widely accepted, cycling tends to produce health benefits and reduce air pollution. Policymakers encourage people to use bikes by improving cycling facilities as well as developing bicycle-sharing systems (BSS). It is increasingly interesting to
Hu, Xuke, Mobasheri, Ali, Sun, Yeran, Wang, Weikai   +3 more
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Public Consciousness of the Transition

Studia Universitatis Babeş-Bolyai Dramatica, 2022
"The decade following the Romanian Revolution, generally known as “the transition,” saw radical changes in the economic and social fabric of the country, with one apparent exception: the public theatre system. At the same time, the monopoly the winners of post-communism developed on the discourse about the transition and the traditional practices of ...
openaire   +1 more source

Integrating Shared Mobility Services with Transit Could Produce Economic and Environmental Benefits [PDF]

, 2020
This research brief summarizes the findings from the associated study, which examined the potential to improve transportation system efficiency by reevaluating and redefining the role of public transit and its design principles in the new context of ...
Fan, Yueyue, Zhang, Yunteng
core