Results 51 to 60 of about 2,130,927 (298)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PUBLIC TRANSPORT AND INNOVATION

International Journal of Advanced Studies, 2019
The effective functioning of the transport system of the region creates the necessary conditions for the development of the economy and the social sphere.
Nina Demidovna Berman, Alexander Mikhailovich Belov   +1 more
doaj   +1 more source

Transport and ageing: Extending quality of life for older people via public and private transport [PDF]

, 2002
Accessible public transport and the independence that comes with car driving are generally thought to be linked to quality of life in old age. However, there has been almost no research on this topic in the UK.
Bainbridge, D, Gilhooly, M, Gow, J, Hamilton, K, O'Neill, M, Pike, F, Webster, N   +6 more
core  

Network Harness: Metropolis Public Transport [PDF]

, 2006
We analyze the public transport networks (PTNs) of a number of major cities of the world. While the primary network topology is defined by a set of routes each servicing an ordered series of given stations, a number of different neighborhood relations ...
Albert, Albert, Amaral, Barabási, Barabási, Barrat, Blavats’ka, C. von Ferber, Cohen, Crucitti, de Gennes, Dorogovtsev, Dorogovtsev, Gastner, Guimera, Guimerà, Harris, Latora, Latora, Li, Marchiori, Mathias, Newman, Nienhuis, Seaton, Sen, Sienkiewicz, T. Holovatch, V. Palchykov, Valverde, von Ferber, von Ferber, von Ferber, Watts, Xu, Yu. Holovatch   +35 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Competitiveness of Public Transport [PDF]

Journal of Competitiveness, 2017
Examining the competitiveness of public transport plays an important role because through public transport, the transport of passengers to schools, public healthcare establishments and work is ensured. In addition, transportation for vulnerable groups of
Poliak Milos, Poliakova Adela, Mrnikova Michaela, Simurková Patricia, Jaskiewicz Marek, Jurecki Rafał   +5 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Regional public transport integration in Lithuania

Mokslas: Lietuvos Ateitis
Regional public transport organization helps to avoid additional route coordination, public transport service should not be limited to the boundaries of municipalities, which is currently regulated by the Law on Local Self-Government of the Republic of ...
Andrius Samuilovas, Rasa Ušpalytė-Vitkūnienė   +1 more
doaj   +1 more source